Results 31 to 40 of about 478,788 (285)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Applications of qualitative grounded theory methodology to investigate hearing loss: protocol for a qualitative systematic review

BMJ Open, 2020
Introduction Hearing loss is a chronic condition affecting 12 million individuals in the UK. People with hearing loss regularly experience difficulties interacting in everyday conversations. These difficulties in communication can result in a person with
Helen Henshaw, Yasmin H K Ali, Nicola Wright, David Charnock, Derek Hoare   +4 more
doaj   +1 more source

Assessing sustainability support to small and medium sized enterprises (SMEs) [PDF]

, 2014
The aim of this paper is to evaluate qualitatively the impact of sustainability support to Small and Medium Sized Enterprises (SMEs) where quantitative results are often difficult to appraise.
Conway, Elaine
core   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Are There Two Methods of Grounded Theory? Demystifying the Methodological Debate

Grounded Theory Review: An International Journal, 2008
Grounded theory is an inductive research method for the generation of substantive or formal theory, using qualitative or quantitative data generated from research interviews, observation, or written sources, or some combination thereof (Glaser & Strauss,
Cheri Ann Hernandez
doaj   +2 more sources

Investigating the Factors Affecting the Financing of Investor Share Cooperatives (Case Study: Pishgaman Kavir Yazd Group) [PDF]

سیاست نامه علم و فناوری, 2021
Cooperative entrepreneurship and the new methods of financing them that are used to attract people funds are more compatible with the beliefs of Islamic societies.
Mohammad Reza Taghva, Habibollah Roudsaz, Mohammad Reza Rezaeinejad   +2 more
doaj  

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

What makes you not a Buddhist? : a preliminary mapping of values [PDF]

, 2012
This study sets out to establish which Buddhist values contrasted with or were shared by adolescents from a non-Buddhist population. A survey of attitude toward a variety of Buddhist values was fielded in a sample of 352 non-Buddhist schoolchildren aged ...
Adamson J., Andolina M. W., Assanangkornchai S., Banks J. A., Berliner D. C., Brewer J. D., Carnap R., Chakravarti S. S., Chamorro-Premuzic T., Choompolpaisal P., Clifford J., Clifford J., Cohen L., Cooper C., Crosby K., Cush D., De Silva P., Delmonico N., Denzin N. K., Erickson F., Fane R. S., Francis L. J., Francis L. J., Francis L. J., Francis L. J., Francis L. J., Furlong J., Garrison J. W., Glaser B. G., Glock C. Y., Hartas D., Hofstede G., Hood R. W., Hubbard J., Jackson R., Jackson R., Kay W. K., Kelly G. J., Kemp S., Khyentse D. J., Kluckhohn C., Loundon S., Loundon S., Maltby J., Pennington D., Phra Nicholas Thanissaro, Popper K. R., Pupatana S., Qualifications and Curriculum Authority [QCA], Rogers P., Scotton B. W., Smart N., Smart N., Smith D. L., Smith W. C., SPSS Inc, Thananart M., Thanissaro P. N., Thanissaro P. N., Thanissaro P. N., Thanissaro P. N., Thanissaro P. N., Tooley J., Tori C. D., Wallace B. A.   +64 more
core   +1 more source

Between qualitative and quantitative methodology: Grounded theory [PDF]

, 2012
The paper presents the foundations of the grounded theory method, which is one of the orientations of qualitative methodology, which originated in the USA in the 1960s. First of all, it highlights the essentially different meanings of the word 'theory' in European (continental) thought and American empirical sociology. The appearance of grounded theory
Milašinović, Srđan, Kešetović, Želimir   +1 more
openaire   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source