Results 81 to 90 of about 2,012,232 (260)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Mobility difference index: a quantitative method for detecting human mobility difference

GIScience & Remote Sensing
Differences in human mobility reflect temporal variations and spatial differences in urban spaces, including regional functions, physical environments, and geographical sentiments.
Zhaohui Liu, Rui Li, Jing Cai, Qiushi Hu, Huayi Wu   +4 more
doaj   +1 more source

Les fluctuations de sens dans quelques formes modales à la lumière d’une approche quantitative et qualitative [PDF]

Studii de Lingvistica, 2016
The expressions discussed in this article – certes, peut-être and sans doute – share the property of conveying a modal meaning (to be understood as non-denotational), which oscillates between an epistemic and a more or less conventionalized concessive ...
Corinne Rossari
doaj  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Cybernetics in philology. Statement of the problem

Неофилология
INTRODUCTION. The relationship between cybernetics and philology is considered. The rapid development of modern technologies, and artificial intelligence in particular, poses the question of introducing programs focused on humanitarian and technological ...
A. Y. Ovtcharenko, E. A. Shaprinskay
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Psikoedukasi “Cerdas Menggunakan Gadget dan Internet untuk Anak”: Upaya untuk Meningkatkan Pengetahuan Literasi Digital Anak

Gadjah Mada Journal of Professional Psychology
Rendahnya literasi digital dapat meningkatkan risiko terpaparnya dampak negatif dari penggunaan gadget dan internet seperti mudah terprovokasi oleh hoaks, \textit{cyberbullying}, dan ujaran kebencian.
Tina Afiatin, Sutarimah Ampuni, Muhammad Ikbal Wahyu Sukron, Anggia Atin Aprila, Salma Nur Hanifah, Zahra Frida Intani   +5 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source