Results 111 to 120 of about 15,493,907 (286)

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Quantitative Structure–Property Relationship Analysis in Molecular Graphs of Some Anticancer Drugs with Temperature Indices Approach

Mathematics
The most important application of anticancer drugs in various forms (alkylating agents, hormones agents, and antimetabolites) is the treatment of malignant diseases.
Xiaolong Shi, Ruiqi Cai, Jaber Ramezani Tousi, Ali Asghar Talebi   +3 more
doaj   +1 more source

Quantitative Structure-Property Relationship Analysis for the Prediction of Propylene Adsorption Capacity in Pure Silicon Zeolites at Various Pressure Levels. [PDF]

ACS Omega, 2022
Zhao L, Zhang Q, He C, Chen Q, Zhang BJ.
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

The property market in China

, 2001
Since the new land tenure system, known as the Land Use Rights system (LUR), was introduced in 1978, there has been significant development in the Chinese property market.
Chan, Nelson, Jia, Shi-Jun
core  

Predictive performance and QSPR analysis of SARS-CoV-2 and tuberculosis drugs using distance-based topological descriptors

Scientific Reports
Topological descriptors from molecular graphs are crucial in quantitative structure–property relationship (QSPR) analysis, linking structure to physicochemical and biological properties. This work studies the detour distance-based index, Detour Eccentric
Supriya, Radha Rajamani Iyer
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Quantitative Structure−Property Relationship for Prediction of the Lower Flammability Limit of Pure Compounds

, 2015
A quantitative structure−property relationship (QSPR) study was performed to develop a model for prediction of the lower flammability limit (LFL) of pure compounds. The obtained model is a four-parameter multilinear equation.
Farhad Gharagheizi (1264443)
core   +1 more source

Quantitative Structure–Property Relationship for High Flash Point of Ester Oil Molecules and Its Experimental Verification

High Voltage
With the increasing voltage of ester oil‐filled transformers and their application in offshore wind power, developing high‐performance, fire‐resistant esters is crucial for enhancing transformer safety.
Jingwen Zhang, Jian Hao, Per‐Olof Åstrand, Hongwei Li, Ruijin Liao   +4 more
doaj   +1 more source

Evaluation of Quantitative Structure Property Relationship Algorithms for Predicting Plasma Protein Binding in Humans. [PDF]

Comput Toxicol, 2021
Yun YE, Tornero-Velez R, Purucker ST, Chang DT, Edginton AN.   +4 more
europepmc   +1 more source