Results 51 to 60 of about 822,180 (287)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A GNN-Based QSPR Model for Surfactant Properties

Colloids and Interfaces
Surfactants are among the most versatile molecules in the chemical industry because they can self-assemble in bulk solutions and at interfaces. Predicting the properties of surfactant solutions, such as their critical micelle concentration (CMC ...
Seokgyun Ham, Xin Wang, Hongwei Zhang, Brian Lattimer, Rui Qiao   +4 more
doaj   +1 more source

Predicting explosibility properties of chemicals from quantitative structure‐property relationships [PDF]

Process Safety Progress, 2010
AbstractQuantitative Structure‐Property Relationship (QSPR) type methods have been up to now mainly devoted to biological, toxicological applications but their use to predict physico‐chemical properties is a growing interest. In this context, an original approach associating QSPR methods and quantum chemical calculations for the prediction of chemicals
Fayet, Guillaume, Rotureau, Patricia, Joubert, Laurent, Adamo, Carlo   +3 more
openaire   +3 more sources

SISSO: a compressed-sensing method for identifying the best low-dimensional descriptor in an immensity of offered candidates

, 2018
The lack of reliable methods for identifying descriptors - the sets of parameters capturing the underlying mechanisms of a materials property - is one of the key factors hindering efficient materials development.
Ahmetcik, Emre, Curtarolo, Stefano, Ghiringhelli, Luca M., Ouyang, Runhai, Scheffler, Matthias   +4 more
core   +1 more source

Geoscience after IT: Part F. Familiarization with quantitative analysis [PDF]

, 2000
Numbers, measurement and calculation extend our view of the world. Statistical methods describe the properties of sets of quantitative data, and can test models (particularly the model that observed relationships arose by chance) and help us to draw ...
Loudon, T.V.
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

QSPR study of the retention/release property of odorant molecules in pectin gels using statistical methods

Journal of Taibah University for Science, 2017
The ACD/ChemSketch, MarvinSketch, and ChemOffice programmes were used to calculate several molecular descriptors of 51 odorant molecules (15 alcohols, 11 aldehydes, 9 ketones and 16 esters).
Assia Belhassan, Samir Chtita, Tahar Lakhlifi, Mohammed Bouachrine   +3 more
doaj   +1 more source

Prediction of degradability of micropollutants by sonolysis in water with QSPR - a case study on phenol derivates

Ultrasonics Sonochemistry, 2022
The increasing quantity and variety of organic contaminants discharged into surface and groundwater increase the necessity of additional and suitable water treatment methods, which can be incorporated into existing wastewater treatment plants.
Judith Glienke, Willy Schillberg, Michael Stelter, Patrick Braeutigam   +3 more
doaj   +1 more source

Rough Set Theory for Real Estate Appraisal: An Application to Directional District of Naples [PDF]

, 2017
This paper proposes an application of Rough Set Theory (RST) to the real estate field, in order to highlight its operational potentialities for mass appraisal purposes.
Cantisani, Giovanni Battista, De Paola, Pierfrancesco, Del Giudice, Vincenzo   +2 more
core   +2 more sources