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Regulatory variation in hepcidin expression as a heritable quantitative trait
Biochemical and Biophysical Research Communications, 2009Genetic variation underlies phenotypic diversity and complex quantitative traits including heritable diseases. We hypothesized that such variation may underlie or determine intrinsic inter-individual differences in iron metabolism and may also play a role in variable phenotypes associated with iron-related diseases.
Henry Bayele, Surjit Srai
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Nature Genetics, 2021
Genome-wide association studies have identified thousands of noncoding variants associated with human traits and diseases. However, the functional interpretation of these variants is a major challenge. Here, we constructed a multi-tissue atlas of human 3'UTR alternative polyadenylation (APA) quantitative trait loci (3'aQTLs), containing approximately 0.
Lei Li +12 more
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Genome-wide association studies have identified thousands of noncoding variants associated with human traits and diseases. However, the functional interpretation of these variants is a major challenge. Here, we constructed a multi-tissue atlas of human 3'UTR alternative polyadenylation (APA) quantitative trait loci (3'aQTLs), containing approximately 0.
Lei Li +12 more
openaire +2 more sources
Anthropologischer Anzeiger, 2016
Heritability is a statistical measure, expressing the proportion of phenotypic variance that is explained by the genetic variance. Heritability of a given trait can vary in time and may differ between populations, which is inter alia associated with interactions and correlations between genotype and environment or population-specific differences ...
Małgorzata, Waszak, Krystyna, Cieślik
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Heritability is a statistical measure, expressing the proportion of phenotypic variance that is explained by the genetic variance. Heritability of a given trait can vary in time and may differ between populations, which is inter alia associated with interactions and correlations between genotype and environment or population-specific differences ...
Małgorzata, Waszak, Krystyna, Cieślik
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IS SURVIVAL TIME AFTER HEMORRHAGE A HERITABLE, QUANTITATIVE TRAIT?
Shock, 2008Enhancing survival to hemorrhage of both civilian and military patients is a major emphasis for trauma research. Previous observations in humans and outbred rats show differential survival to similar levels of hemorrhage. In an initial attempt to determine potential genetic components of such differential outcomes, survival time after a controlled ...
Harold G, Klemcke +7 more
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Heritability estimation of sex‐specific effects on human quantitative traits
Genetic Epidemiology, 2007AbstractRecent studies have suggested that sex‐specific genetic architecture could be because of the effects of autosomal genes that are differentially expressed in males and females. Yet, few studies have explored the effects of X‐linked genes on sex‐specific genetic architecture.
Lin, Pan, Carole, Ober, Mark, Abney
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Heritabilities and quantitative trait loci for blood gases and blood pH in swine
Animal Genetics, 2009SummaryMaintaining pH and blood gases in a narrow range is essential to sustain normal biochemical reactions. Decreased oxygenation, poor tissue perfusion, disturbance to CO2 expiration, and shortage of HCO3− can lead to metabolic acidosis. This is a common situation in swine, and originates from a broad range of medical conditions.
G, Reiner +5 more
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Heritability of quantitative traits
1995Abstract In the most traditional view, heritability is the proportion of total phenotypic variance attributable to additive genetic variance. The latter results from segregation of alleles with additive effects. Other contributors to total variance include dominance, epistatic and environmental effects and covariances and interactions ...
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Human Heredity, 1993
Methods to determine the proportion of variability manifested by a quantitative trait that is attributable to additive genetic effects are important tools for human population and statistical geneticists. Though traditional methods based on parent-offspring and sib-pair correlations have been well researched, they are being steadily supplanted or ...
N J, Schork, M A, Schork
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Methods to determine the proportion of variability manifested by a quantitative trait that is attributable to additive genetic effects are important tools for human population and statistical geneticists. Though traditional methods based on parent-offspring and sib-pair correlations have been well researched, they are being steadily supplanted or ...
N J, Schork, M A, Schork
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Principal Components of Heritability for High Dimension Quantitative Traits and General Pedigrees
Statistical Applications in Genetics and Molecular Biology, 2012For many complex disorders, genetically relevant disease definition is still unclear. For this reason, researchers tend to collect large numbers of items related directly or indirectly to the disease diagnostic. Since the measured traits may not be all influenced by genetic factors, researchers are faced with the problem of choosing which traits or ...
Oualkacha, Karim +4 more
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