Results 151 to 160 of about 361,741 (406)

Derivation of the Shrinkage Estimates of Quantitative Trait Locus Effects [PDF]

Genetics, 2007
AbstractThe shrinkage estimate of a quantitative trait locus (QTL) effect is the posterior mean of the QTL effect when a normal prior distribution is assigned to the QTL. This note gives the derivation of the shrinkage estimate under the multivariate linear model.
openaire   +3 more sources

Genetic Regulation of Alternative Polyadenylation Provides Novel Insights into Molecular Mechanisms Underlying Non‐small Cell Lung Cancer

Advanced Science, EarlyView.
Compared with the non‐risk G allele of rs9606, the risk T allele of rs9606 decreases the binding affinity of NUDT21 for LYRM4, triggering 3'UTR shortening that stabilizes LYRM4 mRNA and elevates its expression. Increased LYRM4 expression promoted malignant phenotypes of non‐small cell lung cancer (NSCLC) cells through modulating ferroptosis, supporting
Meng Jin, Yongbiao Huang, Bin Li, Yuan Wang, Yan Li, Zhirui Chen, Zhe Tang, Chaofan Liu, Lei Zhang, Xianglin Yuan, Jianbo Tian, Bo Liu   +11 more
wiley   +1 more source

Quantitative trait locus mapping of Populus bark features and stem diameter

BMC Plant Biology, 2017
Background Bark plays important roles in photosynthate transport and storage, along with physical and chemical protection. Bark texture varies extensively among species, from smooth to fissured to deeply furrowed, but its genetic control is unknown. This
Roba Bdeir, Wellington Muchero, Yordan Yordanov, Gerald A. Tuskan, Victor Busov, Oliver Gailing   +5 more
doaj   +1 more source

Semiparametric Quantitative-Trait-Locus Mapping: II. on Censored Age-at-Onset [PDF]

, 2004
In genetic studies, the variation in genotypes may not only affect different inheritance patterns in qualitative traits, but may also affect the age-at-onset as quantitative trait.
Chen, Ying Qing, Hu, Chengcheng, Wu, Rongling   +2 more
core   +1 more source

Stability and response of polygenic traits to stabilizing selection and mutation

, 2014
When polygenic traits are under stabilizing selection, many different combinations of alleles allow close adaptation to the optimum. If alleles have equal effects, all combinations that result in the same deviation from the optimum are equivalent ...
Barton, de Vladar, Harold P. de Vladar, Lande, Nick Barton, Slatkin, Turelli, Turelli, Wright   +8 more
core   +1 more source

Mapping of a Blood Pressure Quantitative Trait Locus to Chromosome 15q in a Chinese Population [PDF]

, 1999
Xin Xu, Jianbo Yang, John Rogus, Chen X. Chen, Nicholas J. Schork, Xin Xu   +5 more
openalex   +1 more source

Maize association population: a high-resolution platform for quantitative trait locus dissection.

The Plant Journal, 2005
Crop improvement and the dissection of complex genetic traits require germplasm diversity. Although this necessary phenotypic variability exists in diverse maize, most research is conducted using a small subset of inbred lines.
S. Flint-Garcia, Anne-Céline Thuillet, Jianming Yu, G. Pressoir, Susan Romero, S. Mitchell, J. Doebley, S. Kresovich, M. Goodman, E. Buckler   +9 more
semanticscholar   +1 more source

Genomic Variation Underpins Genetic Divergence and Differing Salt Resilience in Sesbania bispinosa

Advanced Science, EarlyView.
Sesbania, a leguminous halophyte, thrives in saline soils. Comparative genomics reveals key genomic variations—particularly chromosomal inversions—are identified as contributors to population differentiation and salt resilience. These findings advance the understanding of genomic variation driving evolution and phenotypic differentiation and offer ...
Gai Huang, Xiaofei Wang, Chengli Liu, Kaixuan He, Xiu‐Li Hou, Haofei Luo, Shuaibin Zhang, Changqing You, Yajun Jia, Fuqiang Wang, Xianwei Song, Guodao Liu, Xian Deng, Xiaofeng Cao   +13 more
wiley   +1 more source

The gene's eye-view of quantitative genetics [PDF]

arXiv
Modelling the evolution of a continuous trait in a biological population is one of the oldest problems in evolutionary biology, which led to the birth of quantitative genetics. With the recent development of GWAS methods, it has become essential to link the evolution of the trait distribution to the underlying evolution of allelic frequencies at many ...
arxiv  

Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q. [PDF]

, 1997
A. V. Lembertas, Louis Pérusse, Y. C. Chagnon, Janis S. Fisler, Craig H. Warden, D A Purcell-Huynh, France T. Dionne, Jean Gagnon, André Nadeau, Aldons J. Lusis, Claude Bouchard   +10 more
openalex   +1 more source