Results 181 to 190 of about 3,713,588 (257)

Integration of single-cell cis-expression quantitative trait locus and Mendelian randomization analyses identifies a Treg-specific gene for precision therapy in rheumatoid arthritis, gonarthrosis, and gouty arthritis. [PDF]

J Int Med Res
Ren T, Shen Y, Li J, Zhang Z, Liu Z, Bao L, Li X.   +6 more
europepmc   +1 more source

Molecular mechanism of Xanthotoxol against gastric cancer: A comprehensive study integrating network pharmacology, computer simulations, and experimental validation

Animal Models and Experimental Medicine, EarlyView.
Our study systematically explored the anti‐gastric cancer (GC) mechanism of Xanthotoxol (Xan), a natural active phytochemical, using an integrated strategy of network pharmacology, molecular simulation, and experimental validation. First, we identified 39 hub genes associated with gastric cancer using weighted gene co‐expression network analysis (WGCNA)
Yi Yang, Yu‐Hua Du, Chuang Song, Lan‐Nv Ma, Lin Luo, De‐Xu Xu, Xiao‐Yan Ma, Zi‐Ying Zhou, Yi Nan, Yi Yang, Ling Yuan   +10 more
wiley   +1 more source

<i>Tetratricopeptide Repeat 2</i> Is a Quantitative Trait Locus That Controls Seed Size. [PDF]

Int J Mol Sci
Wang Z, Cara S, Rhee SY, Hauser BA.
europepmc   +1 more source

Developing a strain‐dependent susceptibility to hepatocellular carcinoma in a murine model based on histopathological evidence and genetic context

Animal Models and Experimental Medicine, EarlyView.
Using F1 (C57BL/6J/Smad4+/− X CC) mice, we found that partial loss of Smad4 promotes liver carcinogenesis in a strain‐dependent manner, highlighting the importance of genetic modifiers in tumor susceptibility. The use of Collaborative Cross mice provides a valuable platform for uncovering genotype‐specific cancer susceptibilities in preclinical ...
Osayd Zohud, Aysar Nashef, Imad Abu‐Elnaaj, Fuad A. Iraqi   +3 more
wiley   +1 more source

Mapping of quantitative trait locus for resistance to anthracnose in a population derived from genotypes PI 527538 and Ervilha of common bean. [PDF]

Front Plant Sci
Mulube M, Hamabwe S, Kuwabo K, Chinji M, Nkandela M, Botha J, Mwense B, Tembo L, Lungu D, Mukuma C, Parker T, Kamfwa K.   +11 more
europepmc   +1 more source

Biallelic PIGB Variants Cause Motor Neuropathy with Conduction Blocks and Peripheral Nerve Hyperexcitability

Annals of Neurology, EarlyView.
Objective Glycosylphosphatidylinositol (GPI)‐anchored proteins play critical roles in nervous system function. Pathogenic variants in genes involved in GPI‐anchor biosynthesis cause early‐onset multisystem disorders known as inherited GPI deficiencies. We describe a novel neuromuscular phenotype associated with PIGB deficiency.
Gorka Fernández‐Eulate, Romain Duval, Marina Konyukh, Alessandro Bertini, Ayse Candayan, Albena Jordanova, Theresa Brunet, Wolfgang Müller‐Felber, Helena F. Pernice, Katrin Hahn, Nadja Ehmke, Juliane Beuschlein, Bertrand Isidor, Benjamin Cogné, Yann Péréon, Annabelle Chaussenot, John Rendu, Aysylu Murtazina, Dmitrii Subbotin, Artem Borovikov, Andrey Marakhonov, Chiara Pisciotta, Paola Saveri, Daniele Cazzato, Lucie Lemeray, Bérengère Koehl, Jean‐Madeleine de Sainte‐Agathe, Stefano Facchini, Ilaria Quartesan, Andrea Cortese, Yesim Parman, Arman Cakar, Davide Pareyson, Slim Azouzi, Tanya Stojkovic   +34 more
wiley   +1 more source

Protein quantitative trait locus analysis in African American and non-Hispanic White individuals. [PDF]

Genome Biol
Cai Y, Johnson M, Haessler J, Molstad AJ, Hwang SJ, Joehanes R, Murabito JM, Tahir UA, Franceschini N, Gerszten RE, Sun W, Levy D, Raffield LM, Kooperberg C, Hsu L, Reiner AP.   +15 more
europepmc   +1 more source

Genetic bases of resistance to the rice hoja blanca disease deciphered by a quantitative trait locus approach. [PDF]

G3 (Bethesda), 2023
Silva A, Montoya ME, Quintero C, Cuasquer J, Tohme J, Graterol E, Cruz M, Lorieux M.   +7 more
europepmc   +1 more source

Genome-wide association and biparental mapping revealed a major quantitative trait locus associated with seedling resistance to bacterial leaf streak in durum. [PDF]

Theor Appl Genet
Manan F, Li X, Szabo-Hever A, Shi G, Elias E, Faris J, Xu SS, Liu Z.   +7 more
europepmc   +1 more source

Genome-wide association study and fine-mapping identify a major quantitative trait locus controlling hundred-seed weight in soybean. [PDF]

Front Plant Sci
Zhang C, Hong H, Yuan R, Zhang S, Gao T, Yan S, Lamlom SF, Ren H, Liu Z, Wang J.   +9 more
europepmc   +1 more source