Results 11 to 20 of about 141,382 (327)

Expression quantitative trait locus mapping of extracellular microRNAs in human plasma [PDF]

iScience
Summary: MicroRNAs, crucial in regulating protein-coding gene expression, are implicated in various diseases. We performed a genome-wide association study of plasma miRNAs (ex-miRNAs) in 3,743 Framingham Heart Study (FHS) participants and identified 1 ...
Tianxiao Huan, Roby Joehanes, Jian Rong, Ming-Huei Chen, Rima Mustafa, Abbas Dehghan, Mohsen Ghanbari, Hannah Karlin, Shih-Jen Hwang, Paul Courchesne, Martin G. Larson, Andrew D. Johnson, Jane E. Freedman, Daniel Levy   +13 more
doaj   +2 more sources

Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype.

PLoS Biology, 2007
Deficits in prepulse inhibition (PPI) are a biological marker for schizophrenia. To unravel the mechanisms that control PPI, we performed quantitative trait loci (QTL) analysis on 1,010 F2 mice derived by crossing C57BL/6 (B6) animals that show high PPI ...
Akiko Watanabe, Tomoko Toyota, Yuji Owada, Takeshi Hayashi, Yoshimi Iwayama, Miho Matsumata, Yuichi Ishitsuka, Akihiro Nakaya, Motoko Maekawa, Tetsuo Ohnishi, Ryoichi Arai, Katsuyasu Sakurai, Kazuo Yamada, Hisatake Kondo, Kenji Hashimoto, Noriko Osumi, Takeo Yoshikawa   +16 more
doaj   +4 more sources

The anterior nucleus of the thalamus plays a role in the epileptic network

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2010-2024, December 2022., 2022
Abstract Objectives We investigated both the metabolic differences and interictal/ictal discharges of the anterior nucleus of the thalamus (ANT) in patients with epilepsy to clarify the relationship between the ANT and the epileptic network. Methods Nineteen patients with drug‐resistant epilepsy who underwent stereoelectroencephalography were studied ...
Hao Yan, Xueyuan Wang, Tao Yu, Duanyu Ni, Liang Qiao, Xiaohua Zhang, Cuiping Xu, Wei Shu, Yuping Wang, Liankun Ren   +9 more
wiley   +1 more source

The Dissection of Expression Quantitative Trait Locus Hotspots [PDF]

Genetics, 2016
AbstractStudies of the genetic loci that contribute to variation in gene expression frequently identify loci with broad effects on gene expression: expression quantitative trait locus hotspots. We describe a set of exploratory graphical methods as well as a formal likelihood-based test for assessing whether a given hotspot is due to one or multiple ...
Christina Kendziorski, Alan D. Attie, Mark P. Keller, Jianan Tian, Brian S. Yandell, Karl W. Broman, Aimee Teo Broman   +6 more
openaire   +4 more sources

Identification of stable QTL controlling multiple yield components in a durum × cultivated emmer wheat population under field and greenhouse conditions

G3: Genes, Genomes, Genetics, 2022
Crop yield gains are needed to keep pace with a growing global population and decreasing resources to produce food. Cultivated emmer wheat is a progenitor of durum wheat and a useful source of genetic variation for trait improvement in durum.
Amanda R Peters Haugrud, Qijun Zhang, Andrew J Green, Steven S Xu, Justin D Faris   +4 more
doaj   +1 more source

PM20D1 is a quantitative trait locus associated with Alzheimer’s disease [PDF]

Nature Medicine, 2018
The chances to develop Alzheimer's disease (AD) result from a combination of genetic and non-genetic risk factors 1 , the latter likely being mediated by epigenetic mechanisms 2 . In the past, genome-wide association studies (GWAS) have identified an important number of risk loci associated with AD pathology 3 , but a causal relationship remains ...
Jose V. Sanchez-Mut, Holger Heyn, Bianca A. Silva, Lucie Dixsaut, Paula Garcia-Esparcia, Enrique Vidal, Sergi Sayols, Liliane Glauser, Ana Monteagudo-Sánchez, Jordi Perez-Tur, Isidre Ferrer, David Monk, Bernard Schneider, Manel Esteller, Johannes Gräff   +14 more
openaire   +9 more sources

The X Chromosome in Quantitative Trait Locus Mapping [PDF]

Genetics, 2006
AbstractThe X chromosome requires special treatment in the mapping of quantitative trait loci (QTL). However, most QTL mapping methods, and most computer programs for QTL mapping, have focused exclusively on autosomal loci. We describe a method for appropriate treatment of the X chromosome for QTL mapping in experimental crosses.
Broman, K W, Sen, S, Owens, S E, Manichaikul, A, Southard, Smith E, Churchill, G A   +5 more
openaire   +3 more sources

Detection of QTL for traits related to adaptation to sub-optimal climatic conditions in chickens

Genetics Selection Evolution, 2017
Background Growth traits can be used as indicators of adaptation to sub-optimal conditions. The current study aimed at identifying quantitative trait loci (QTL) that control performance under variable temperature conditions in chickens.
Ching-Yi Lien, Michèle Tixier-Boichard, Shih-Wen Wu, Woei-Fuh Wang, Chen Siang Ng, Chih-Feng Chen   +5 more
doaj   +1 more source

Mapping of Two Major QTLs Controlling Flowering Time in Brassica napus Using a High-Density Genetic Map

Plants, 2022
Research on the flowering habit of rapeseed is important for the selection of varieties adapted to specific ecological environments. Here, quantitative trait loci (QTL) for the days-to-flowering trait were identified using a doubled haploid population of
Lei Chen, Weixia Lei, Wangfei He, Yifan Wang, Jie Tian, Jihui Gong, Bing Hao, Xinxin Cheng, Yingjie Shu, Zhixiong Fan   +9 more
doaj   +1 more source

The best of both worlds: Combining population genetic and quantitative genetic models [PDF]

, 2021
Numerous traits under migration-selection balance are shown to exhibit complex patterns of genetic architecture with large variance in effect sizes. However, the conditions under which such genetic architectures are stable have yet to be investigated, because studying the influence of a large number of small allelic effects on the maintenance of ...
arxiv   +1 more source