Results 11 to 20 of about 361,741 (406)

A molecular quantitative trait locus map for osteoarthritis [PDF]

Nature Communications, 2021
Understanding the molecular effects of disease variants in relevant tissues is essential to understanding and treating disease. Here, the authors discover expression and protein quantitative trait loci in cartilage and synovium from 115 osteoarthritis ...
Julia Steinberg, Lorraine Southam, Theodoros I. Roumeliotis, Matthew J. Clark, Raveen L. Jayasuriya, Diane Swift, Karan M. Shah, Natalie C. Butterfield, Roger A. Brooks, Andrew W. McCaskie, J. H. Duncan Bassett, Graham R. Williams, Jyoti S. Choudhary, J. Mark Wilkinson, Eleftheria Zeggini   +14 more
doaj   +8 more sources

Automated quantitative trait locus analysis (AutoQTL) [PDF]

BioData Mining, 2023
Background Quantitative Trait Locus (QTL) analysis and Genome-Wide Association Studies (GWAS) have the power to identify variants that capture significant levels of phenotypic variance in complex traits.
Philip J. Freda, Attri Ghosh, Elizabeth Zhang, Tianhao Luo, Apurva S. Chitre, Oksana Polesskaya, Celine L. St. Pierre, Jianjun Gao, Connor D. Martin, Hao Chen, Angel G. Garcia-Martinez, Tengfei Wang, Wenyan Han, Keita Ishiwari, Paul Meyer, Alexander Lamparelli, Christopher P. King, Abraham A. Palmer, Ruowang Li, Jason H. Moore   +19 more
doaj   +7 more sources

The dissection of expression quantitative trait locus hotspots [PDF]

arXiv, 2015
Studies of the genetic loci that contribute to variation in gene expression frequently identify loci with broad effect on gene expression: expression quantitative trait locus (eQTL) hotspots. We describe a set of exploratory graphical methods as well as a formal likelihood-based test for assessing whether a given hotspot is due to one or multiple ...
Jianan Tian, M. Keller, A. Broman, C. Kendziorski, B. Yandell, A. Attie, K. Broman   +6 more
arxiv   +8 more sources

Covariance between relatives for a marked quantitative trait locus [PDF]

Genetics Selection Evolution, 1995
Summary - Best linear unbiased prediction (BLUP) can be applied to marker-assisted selection. This application requires computation of the inverse of the conditional covariance matrix (Gof additive effects for the quantitative trait locus (QTL) linked to the marker locus (ML), given marker genotypes.
van Arendonk JAM, Grossman M, Beek S, Fernando RL, Wang T   +4 more
doaj   +7 more sources

Multiple-trait quantitative trait locus mapping with incomplete phenotypic data [PDF]

BMC Genetics, 2008
Background Conventional multiple-trait quantitative trait locus (QTL) mapping methods must discard cases (individuals) with incomplete phenotypic data, thereby sacrificing other phenotypic and genotypic information contained in the discarded cases. Under
Guo Zhigang, Nelson James C
doaj   +8 more sources

Complex genetic interactions in a quantitative trait locus. [PDF]

PLoS Genetics, 2006
Whether in natural populations or between two unrelated members of a species, most phenotypic variation is quantitative. To analyze such quantitative traits, one must first map the underlying quantitative trait loci.
Himanshu Sinha, Bradly P Nicholson, Lars M Steinmetz, John H McCusker   +3 more
doaj   +6 more sources

PM20D1 is a quantitative trait locus associated with Alzheimer’s disease [PDF]

Nature Medicine, 2018
The chances to develop Alzheimer's disease (AD) result from a combination of genetic and non-genetic risk factors 1 , the latter likely being mediated by epigenetic mechanisms 2 . In the past, genome-wide association studies (GWAS) have identified an important number of risk loci associated with AD pathology 3 , but a causal relationship remains ...
J. Sanchez-Mut, H. Heyn, Bianca A. Silva, Lucie Dixsaut, Paula Garcia-Esparcia, E. Vidal, Sergi Sayols, Liliane Glauser, Ana Monteagudo-Sánchez, J. Pérez-Tur, I. Ferrer, D. Monk, B. Schneider, M. Esteller, Johannes Gräff   +14 more
semanticscholar   +9 more sources

Combined expression trait correlations and expression quantitative trait locus mapping. [PDF]

PLoS Genetics, 2006
Coordinated regulation of gene expression levels across a series of experimental conditions provides valuable information about the functions of correlated transcripts.
Hong Lan, Meng Chen, Jessica B Flowers, Brian S Yandell, Donnie S Stapleton, Christine M Mata, Eric Ton-Keen Mui, Matthew T Flowers, Kathryn L Schueler, Kenneth F Manly, Robert W Williams, Christina Kendziorski, Alan D Attie   +12 more
doaj   +7 more sources

Mapping of a Quantitative Trait Locus for Stay-Green Trait in Common Wheat [PDF]

Plants
The stay-green (SG) trait enhances photosynthetic activity during the late grain-filling period, benefiting grain yield under drought and heat stresses. CH7034 is a wheat breeding line with SG.
Xin Li, Xin Bai, Lijuan Wu, Congya Wang, Xinghui Liu, Qiqi Li, Xiaojun Zhang, Fang Chen, Chengda Lu, Wei Gao, Tianling Cheng   +10 more
doaj   +2 more sources

fw2.2 : A Quantitative Trait Locus Key to the Evolution of Tomato Fruit Size [PDF]

Science, 2000
Domestication of many plants has correlated with dramatic increases in fruit size. In tomato, one quantitative trait locus (QTL), fw2.2, was responsible for a large step in this process.
Anne Frary, Teresa Nesbitt, Amy Frary, Silvana Grandillo, Esther van der Knaap, Bin Cong, Jiping Liu, Jarek Meller, Ron Elber, Kevin B. Alpert, Steven D. Tanksley   +10 more
openalex   +2 more sources