Automated quantitative trait locus analysis (AutoQTL) [PDF]
BioData Mining, 2023 Background Quantitative Trait Locus (QTL) analysis and Genome-Wide Association Studies (GWAS) have the power to identify variants that capture significant levels of phenotypic variance in complex traits.
Philip J. Freda +19 more
doaj +7 more sources
Mapping of a Quantitative Trait Locus for Stay-Green Trait in Common Wheat [PDF]
PlantsThe stay-green (SG) trait enhances photosynthetic activity during the late grain-filling period, benefiting grain yield under drought and heat stresses. CH7034 is a wheat breeding line with SG.
Xin Li +10 more
doaj +4 more sources
Multiple-trait quantitative trait locus mapping with incomplete phenotypic data [PDF]
BMC Genetics, 2008 Background Conventional multiple-trait quantitative trait locus (QTL) mapping methods must discard cases (individuals) with incomplete phenotypic data, thereby sacrificing other phenotypic and genotypic information contained in the discarded cases. Under
Guo Zhigang, Nelson James C
doaj +5 more sources
Complex genetic interactions in a quantitative trait locus. [PDF]
PLoS Genetics, 2006 Whether in natural populations or between two unrelated members of a species, most phenotypic variation is quantitative. To analyze such quantitative traits, one must first map the underlying quantitative trait loci.
Himanshu Sinha +3 more
doaj +5 more sources
Combined expression trait correlations and expression quantitative trait locus mapping. [PDF]
PLoS Genetics, 2006 Coordinated regulation of gene expression levels across a series of experimental conditions provides valuable information about the functions of correlated transcripts.
Hong Lan +12 more
doaj +6 more sources
A molecular quantitative trait locus map for osteoarthritis [PDF]
Nature Communications, 2021 Understanding the molecular effects of disease variants in relevant tissues is essential to understanding and treating disease. Here, the authors discover expression and protein quantitative trait loci in cartilage and synovium from 115 osteoarthritis ...
Julia Steinberg +14 more
doaj +6 more sources
Genome shuffling enables quantitative trait locus mapping in Bacillus subtilis [PDF]
Nature CommunicationsGenetic mapping is a powerful tool for eukaryotic genetics that has only been applied to bacteria in limited circumstances. Quantitative trait locus (QTL) mapping generally relies on sexual recombination to break linkages between genes, yet bacteria ...
Delyana P. Vasileva +18 more
doaj +2 more sources
Expression quantitative trait locus analysis for translational medicine [PDF]
Genome Medicine, 2015 AbstractExpression quantitative trait locus analysis has emerged as an important component of efforts to understand how genetic polymorphisms influence disease risk and is poised to make contributions to translational medicine. Here we review how expression quantitative trait locus analysis is aiding the identification of which gene(s) within regions ...
Gibson, Greg +2 more
openaire +6 more sources
Expression quantitative trait locus mapping of extracellular microRNAs in human plasma [PDF]
iScienceSummary: MicroRNAs, crucial in regulating protein-coding gene expression, are implicated in various diseases. We performed a genome-wide association study of plasma miRNAs (ex-miRNAs) in 3,743 Framingham Heart Study (FHS) participants and identified 1 ...
Tianxiao Huan +13 more
doaj +2 more sources
Dissecting the Genetic Basis of Yield Traits and Validation of a Novel Quantitative Trait Locus for Grain Width and Weight in Rice [PDF]
PlantsGrain yield in rice is a complex trait and it is controlled by a number of quantitative trait loci (QTL). To dissect the genetic basis of rice yield, QTL analysis for nine yield traits was performed using an F2 population containing 190 plants, which was
Man Yin +7 more
doaj +2 more sources