Results 311 to 320 of about 283,140 (381)

Lipid metabolism and inflammation as key drivers in preterm birth: A comprehensive analysis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To investigate the alterations in lipid metabolites and circulating inflammatory factors associated with preterm birth, elucidate their interactions, and uncover the underlying pathophysiologic mechanisms. By identifying potential predictive biomarkers and informing the development of effective therapeutic interventions, this ...
Shu Xiao, ChaoChao Wei
wiley   +1 more source

Extrachromosomal Circular DNA: Emerging Insights Into Cardiovascular Disease Mechanisms and Biomarker Potential

iLABMED, EarlyView.
Extrachromosomal circular DNA (eccDNA) has quite recently turned out to be a cardinal component in cardiovascular diseases (CVD), governing the gene expression and mechanisms of disease causation. Studies indicated an upregulation of eccDNA in pulmonary arterial hypertension (PAH), which makes it strikingly potential as a sensitive and specific ...
Saim Mahmood Khan, Jawairya Muhammad Hussain, Surraiya Riaz Mahmood Khan, Bushra Nadeem, Taniyat Naseem, Hammad Jawed, Aina Lashari   +6 more
wiley   +1 more source

CD4⁺ Effective Memory T Cell Markers GBP2 and LAG3 Are Risk Factors for PTB and COVID-19 Infection: A Study Integrating Single-Cell Expression Quantitative Trait Locus and Mendelian Randomization Analyses. [PDF]

Int J Mol Sci
Zhu L, Wu H, Peng L, Huang X, Yang R, Ma W, Zhong L, Li B, Song J, Luo S, Gao L, Wu X, Ma W, Bao F, Liu A.   +14 more
europepmc   +1 more source

Haplotype‐resolved genome and pan‐genome graphs reveal the impacts of structural variation on functional genome and feather colors in chickens

iMetaOmics, EarlyView.
This study built a Wenchang chicken haplotype genome and integrated it with 29 others to create a chicken pangenome atlas. Analysis of 354 chickens revealed 185,205 structural variations (SVs), with one‐third derived from homology‐based and transposable elements.
Lihong Gu, Chen Peng, Anhong Chen, Kaiyu Chen, Xinli Zheng, Dongyou Yu, Zhengguang Wang, Lingzhao Fang, George E. Liu, Pengju Zhao   +9 more
wiley   +1 more source

Dual‐pronged genome engineering: Enhancing crop resistance through elite allele pyramiding and susceptibility gene editing

iMetaOmics, EarlyView.
Developing durable crop disease resistance remains a primary breeding objective, achievable through pyramiding resistance genes and editing susceptibility (S) genes. A recent study identified 10 stable Verticillium wilt resistance genes and eight negative regulators via integrated genome‐wide association studies and transcriptome‐wide association ...
Qingdong Zeng, Zhensheng Kang
wiley   +1 more source

High-Density Genetic Map Construction and Quantitative Trait Locus Analysis of Fruit- and Oil-Related Traits in Camellia oleifera Based on Double Digest Restriction Site-Associated DNA Sequencing. [PDF]

Int J Mol Sci
Lin P, Chai J, Wang A, Zhong H, Wang K.
europepmc   +1 more source

Cold atmospheric plasma combined with nanoparticles in cancer therapy

Interdisciplinary Medicine, EarlyView.
Cold atmospheric plasma (CAP) generates a range of reactive oxygen and nitrogen species (RONS), including singlet oxygen (1O2), hydrogen peroxide (H2O2), hydroxyl radicals (·OH), nitrate (NO3− ${{\text{NO}}_{3}}^{-}$), and nitrite (NO2− ${{\text{NO}}_{2}}^{-}$), which induce oxidative stress and apoptosis in cancer cells.
Yunhao Wang, Fei Cao, Gbenga A. Martins, Qiujie Fang, Yifan Lin, Zhaowei Chen, Guojun Chen, Zhitong Chen   +7 more
wiley   +1 more source

Genome-Wide Association Studies on Chinese Wheat Cultivars Reveal a Novel Fusarium Crown Rot Resistance Quantitative Trait Locus on Chromosome 3BL. [PDF]

Plants (Basel)
Wang C, Sun M, Zhang P, Ren X, Zhao S, Li M, Ren Z, Yuan M, Ma L, Liu Z, Wang K, Chen F, Li Z, Wang X.   +13 more
europepmc   +1 more source

From multi‐omics to precision medicine in intracranial aneurysm: Biomarker discovery and multimodal integration

Interdisciplinary Medicine, EarlyView.
This review explores intracranial aneurysm biomarker discovery through multi‐omics. It reveals key genes, proteins, and metabolites, and shows how machine‐learning‐based multi‐modal integration may aid diagnosis and treatment. Abstract Despite extensive research, currently, no biomarkers are available for clinical use in intracranial aneurysm (IA ...
Jiaxin Zhang, Yufei Yang, Bingxu Chen, Yanmeng Zhao, Haitao Sun   +4 more
wiley   +1 more source