Results 181 to 190 of about 8,919 (266)

Environmentally dependent wood density influences forest structure and dynamics in a demographic vegetation model. [PDF]

Quant Plant Biol
Voss AK, Olin S, Zhou H, Fonti P, Eckes-Shephard AH.   +4 more
europepmc   +1 more source

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

Bouveret Syndrome Presenting as Duodenal Bulb Stenosis and Gastric Outlet Obstruction: A Case Report. [PDF]

Cureus
Doukas PG, Santharaman A, Barofsky AB, Pimpinelli M, Broder A.   +4 more
europepmc   +1 more source

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

Advanced Science, EarlyView.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang, Xiaoqing Gong, Shukai Gu, Jing Li, Bo Liu, Yanan Tian, Qianqian Zhang, Xiaojun Yao, Huanxiang Liu   +8 more
wiley   +1 more source

The utility of 4D flow MRI and computational fluid dynamics in developing the fontan model enhances presurgical planning and ensures better outcomes: the first case report in Thailand. [PDF]

J Cardiothorac Surg
Khunatorn Y, Woragidpoonpol S, Srisuwan T, Taksaudom N, Rattanang J, Chindarungrueangkun P, Khruasingkeaw S, Sawamool N, Saengsin K.   +8 more
europepmc   +1 more source

Hierarchical Ordering Induced Ultrahigh Cryogenic Strength and Strain Hardening in a Ni2CoFeV Medium‐Entropy Alloy

Advanced Science, EarlyView.
A tri‐phase Ni2CoFeV medium‐entropy alloy with fcc, κ, and L12 phases achieves exceptional cryogenic strength‐ductility synergy at 77 K. It delivers a yield strength of 1.4 GPa, an ultimate tensile strength of 2.07 GPa and a tensile ductility of 28%.
Lei Gu, Wei Jiang, Qingzhong Mao, Xiang Chen, Yonghao Zhao   +4 more
wiley   +1 more source

A comprehensive characteristic of Anastatica hierochuntica. [PDF]

Sci Rep
Zhou T, Maimait K, Xu H, Pan L.
europepmc   +1 more source

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

Advanced Science, EarlyView.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen, Mingyue Shen, Rui Zhang, Zhibing Huang, Hui Niu, Qiang Yu, Yi Chen, Xiangwen Pan, Liyuan Rong, Huiliang Wen, Jun Yang, Jianhua Xie   +11 more
wiley   +1 more source

Ontogenetic shifts in wood anatomy and leaf traits in tropical dry forests. [PDF]

New Phytol
Williams PJ, Zipkin EF, González-Melo A, Salgado-Negret B, González-M R, Norden N, Benavides-Tocarruncho JP, Cely JM, Ferrer JA, García-Villalobos D, Garzón F, Idárraga-Piedrahita Á, López-Camacho R, Moreno E, Nieto J, Pizano C, Puentes-Marín J, Pulido N, Rivera K, Rojas-Bautista F, Salinas V, Solorzano JF, Umaña MN.   +22 more
europepmc   +1 more source

NLSS3 Impairs SHM1 Autophagic Degradation to Regulate Leaf Morphology and Salt Tolerance in Rice

Advanced Science, EarlyView.
In rice, NLSS3 binds and shields SHM1 from autophagic degradation to maintain serine homeostasis. The A132P mutation in nlss3 disrupts this, triggering SHM1 loss, metabolic dysfunction, K+ imbalance, and impaired ROS scavenging, which collectively drive narrow leaves and salt sensitivity.
Xiong Liu, Yulu Yang, Zhiqi Hao, Jing Xu, Huibo Zhao, Qiang Zhang, Deyong Ren, Xia Li, Guojun Dong, Lan Shen, Li Zhu, Jiang Hu, Zhenyu Gao, Qing Li, Qian Qian, Guangheng Zhang   +15 more
wiley   +1 more source