Results 131 to 140 of about 3,533,939 (302)

Modelling protein-protein interactions for the design of vaccine chimeric antigens with protective epitopes.

PLoS ONE
Ticks and tick-borne diseases are a growing burden worldwide and vaccines are effective control interventions. Vaccine formulations with tick antigens such as BM86/BM95 (BM) and Subolesin (SUB) have shown reduction in tick fitness and infestation in ...
Marinela Contreras, Marta Rafael, Isidro Sobrino, Consuelo Almazán, Juan J Pastor Comín, James J Valdés, Carlos Roberto Prudencio, Daniel Ferreira de Lima Neto, Veniamin A Borin, Pratul K Agarwal, Paul D Kasaija, Rubén Fernández-Melgar, Justus Rutaisire, José de la Fuente   +13 more
doaj   +1 more source

Real‐Time In Vivo Visualization of Tumor‐Associated Macrophage Reprogramming Using a Nitric Oxide‐Activatable NIR‐II Nanoinducer

Advanced Science, EarlyView.
Reprogramming tumor‐associated macrophages is a promising therapeutic strategy for solid tumors. Here, a nitric oxide (NO)‐activatable NIR‐II fluorescence/photoacoustic nanoinducer (I/E@M2pep) that simultaneously facilitates and visualizes the repolarization of TAMs to an M1‐like phenotype is reported, thereby enhancing anti‐tumor efficacy through M1 ...
Qian Chen, Meng Li, Tuanwei Li, Chen Yang, Xiaohu Yang, Hongchao Yang, Yejun Zhang, Chunyan Li, Qiangbin Wang   +8 more
wiley   +1 more source

A quantum machine learning framework for predicting drug sensitivity in multiple myeloma using proteomic data

Scientific Reports
In this paper, we introduce QProteoML, a new quantum machine learning (QML) framework for predicting drug sensitivity in Multiple Myeloma (MM) using high-dimensional proteomic data. MM, an extremely heterogeneous condition, displays often mixed responses
M. Priyadharshini, B. Deevena Raju, A. Faritha Banu, P. Jagdish Kumar, V. Murugesh, Oleg Rybin   +5 more
doaj   +1 more source

Efficient Implementation of Keyless Signatures with Hash Sequence Authentication [PDF]

, 2014
We present new ideas for decreasing the size of secure memory needed for hardware implementations of hash-sequence based signatures proposed recently by Buldas, Laanoja and Truu (in the following referred to as BLT).
Ahto Buldas, Ahto Truu, Risto Laanoja
core  

Dual‐Mode Type I/II Photosensitization of a Stable Mesoporous Hydrogen‐Bonded Organic Framework for Antibacterial Therapy

Advanced Science, EarlyView.
A π‐conjugated donor–acceptor PDI monomer undergoes hydrogen‐bonded self‐assembly to form a robust mesoporous framework. The ordered molecular arrangement promotes efficient intersystem crossing and charge separation, leading to simultaneous Type I and Type II reactive oxygen species generation with a high singlet oxygen quantum yield.
Yi‐Lun Cheng, Hui Yuan, Yuhang Li, Zi‐Yu Wang, Rui Wang, Qi Yin, Xue‐Ning Ren, Miao Zheng, Yi Zeng, Tian‐Fu Liu, Zaisheng Ye   +10 more
wiley   +1 more source

Developing Hybrid Post-Quantum Encryption Frameworks for U.S. Databases Integrating Financial, Governmental, and Critical Infrastructure Protections [PDF]

PurposeThe rapid evolution of quantum computing is a major menace to the current cryptography design and poses a risk to the confidentiality of sensitive data in the financial, government/critical infrastructure arena of the United States.
Choain, Arafat Hossain Khan, Majumder, Chinmoy, Nasir , Md Abu, Sultana , Nasrin   +3 more
core   +1 more source

Selenium‐Based Nanoplatforms: An Emerging Theranostic Paradigm for Gynecological Cancers

Advanced Science, EarlyView.
This reivew summarizes Selenium as a multifunctional anticancer regulator in gynecological cancers. It reduces tumor risk, enhances therapeutic efficacy, and reduces treatment toxicity. Selenium also overcomes chemoraditherapy resistance, improving overall treatment outcomes. ABSTRACT Gynecological cancers present significant therapeutic challenges due
Hejing Liu, Yujia Zhou, Zihan Zhang, Rong Ma, Luyi Ruan, Liqing Miao, Boxin Zhang, Huihui Ji, Tianfeng Chen, Xueqiong Zhu   +9 more
wiley   +1 more source

Dumbbell‐Structured Plasmonic‐Enhanced Optical Nanoprobes Boosting Photo‐Magnetic‐Acoustic Multimodal Imaging‐Guided Photodynamic‐Photothermal Synergistic Treatment and Immunogenic Death in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
This study reports a novel rationally‐designed optical nanoprobe based on dumbbell‐shaped mesoporous silica‐coated gold nanorods, loaded with rare‐earth oxides, photosensitizers, and tumor‐targeted peptides, enabling plasmonic‐enhanced multimodal imaging and PTT‐PDT synergy.
Baikang Zhuang, Yubiao Yang, Wen Han, Yi Tang, Chengxin Yao, Fuli Zhao, Wenxiao Fang, Jinjie Li, Xiaolan Huo, Yiqian An, Yuanzhi Shao, Botao Gao, Jinchang Yin   +12 more
wiley   +1 more source

Bridging the Gap to Next Generation Power System Planning and Operation with Quantum Computation

Innovative solutions and developments are being inspected to tackle rising electrical power demand to be supplied by clean forms of energy. The integration of renewable energy generations, varying nature loads, importance of active role of distribution ...
Cortiana, Giorgio, Ganeshamurthy, Priyanka Arkalgud, Ghosh, Kumar, O'Meara, Corey, Schiefelbein-Lach, Jan   +4 more
core  

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source