Results 51 to 60 of about 361,516 (268)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Quantum groups and quantum cohomology [PDF]
Astérisque, 2019 In this paper, we study the classical and quantum equivariant cohomology of Nakajima quiver varieties for a general quiver Q. Using a geometric R-matrix formalism, we construct a Hopf algebra Y_Q, the Yangian of Q, acting on the cohomology of these varieties, and show several results about their basic structure theory.
Maulik, D, Okounkov, A
openaire +3 more sources
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
SECURITY OF TEACHING ACTIVITIES ONLINE [PDF]
Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2021 The current pandemic context has led to the rapid transition of all online teaching activities, and the security of all activities has become vulnerable, largely due to limited awareness by students and teachers, creating a security breach through the ...
CARINA-ELENA STEGĂROIU +2 more
doaj
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Development of an Undergraduate Quantum Engineering Degree
IEEE Transactions on Quantum Engineering, 2022 Quantum computing, communications, sensing, and simulations are radically transformative technologies, with great potential to impact industries and economies. Worldwide, national governments, industries, and universities are moving to create a new class
Andrew S. Dzurak +8 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
New Journal of Physics, 2014 Topological invariants, such as the Chern number, characterize topological phases of matter. Here we provide a method to detect Chern numbers in systems with two distinct species of fermion, such as spins, orbitals or several atomic states.
James de Lisle +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source