Results 281 to 290 of about 6,985,730 (379)

Dual‐Locking the SARS‐CoV‐2 Spike Trimer: An Amphipathic Molecular “Bolt” Stabilizes Conserved Druggable Interfaces for Coronavirus Inhibition

Advanced Science, EarlyView.
A new amphipathic molecule, S416 is discovered, that locks the SARS‐CoV‐2 spike protein in its closed state, blocking viral entry. S416 acts as a molecular bolt, binding six sites: three between adjacent RBDs and three connecting NTDs to RBDs. This dual‐locking mechanism stiffens the spike structure and reduces its flexibility.
Shiliang Li, Fang Ye, Yucheng Zheng, Jie Wang, Haoran Peng, Lili Zhu, Lili Chen, Tao Yu, Huan Ge, Jiaqi He, Binghao Zhang, Jiayun Wu, Zhiyi Zhang, Liangliang Jiang, Geng Chen, Ping Zhao, Ke Lan, Zhenjiang Zhao, Xuhong Qian, Ke Xu, Yang Du, Honglin Li   +21 more
wiley   +1 more source

Singular Value Decomposition Quantum Algorithm for Quantum Biology. [PDF]

ACS Phys Chem Au
Oh EK, Krogmeier TJ, Schlimgen AW, Head-Marsden K.   +3 more
europepmc   +1 more source

DiffMC‐Gen: A Dual Denoising Diffusion Model for Multi‐Conditional Molecular Generation

Advanced Science, EarlyView.
DiffMC‐Gen, a dual‐diffusion model for 2D and 3D molecular generation, simultaneously optimizes multiple key objectives across the drug design process, enabling the generation of novel, target‐specific small‐molecule ligands with high therapeutic potential.
Yuwei Yang, Shukai Gu, Bo Liu, Xiaoqing Gong, Ruiqiang Lu, Jiayue Qiu, Xiaojun Yao, Huanxiang Liu   +7 more
wiley   +1 more source

Variational quantum algorithm for node embedding. [PDF]

Fundam Res
Zhou ZR, Li H, Long GL.
europepmc   +1 more source

Quantum algorithm for preparing the ground state of a system via resonance transition. [PDF]

Sci Rep, 2017
Wang H.
europepmc   +1 more source

Complexity measure for continuous-time quantum algorithms [PDF]

, 2001
Dominik Janzing, T. Beth
openalex   +1 more source

Achieving High‐Performance Transcranial Ultrasound Transmission Through Mie and Fano Resonance in Flexible Metamaterials

Advanced Science, EarlyView.
Transcranial ultrasound holds great potential in medical applications. However, effective transcranial ultrasound transmission remains challenging. To address these, this work introduces an innovative Mie‐resonance flexible metamaterial (MRFM), which consists of periodically arranged low‐speed micropillars embedded within a high‐speed flexible ...
Jie Chen, Bing Liu, Genshen Peng, Linming Zhou, Chengwei Tan, Jiale Qin, Juan Li, Zijian Hong, Yongjun Wu, Minghui Lu, Feiyan Cai, Yuhui Huang   +11 more
wiley   +1 more source

Quantum algorithms for solvable groups

, 2001
John Watrous
openalex   +1 more source

Single-pulse preparation of the uniform superpositional state used in quantum algorithms [PDF]

, 2001
G. P. Berman, F. Borgonovi, F. M. Izrailev, V. I. Tsifrinovich   +3 more
openalex   +1 more source

Single‐Pixel Infrared Miniaturized Spectrometer Enabled by Ultra‐Broadband Reconfigurable Photodetection

Advanced Science, EarlyView.
A near‐infrared tunable micro‐spectrometer is achieved by integrating a PbS photodetection unit and a light modulation unit based on liquid crystal tuned optical resonances, demonstrating a wavelength tuning range exceeding 850 nm. This micro‐spectrometer shows high fidelity in spectral reconstruction and is also successfully applied to plastic sorting,
Wenyue Liang, Xianghong Nan, Wenfeng Cai, Ning Tan, Qilin Zheng, Yuyao Lu, Yongyue Huang, Jiahao Yan, Dangyuan Lei, Long Wen, Yanjun Liu, Qin Chen   +11 more
wiley   +1 more source