Results 31 to 40 of about 1,073 (206)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Quantum Reports, 2022 Quantum neurobiology is concerned with potential quantum effects operating in the brain and the application of quantum information science to neuroscience problems, the latter of which is the main focus of the current paper.
Melanie Swan +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Pathophysiology, 2021 Acidosis and its associated pathologies predispose patients to develop cardiac arrhythmias and even cardiac arrest. These arrhythmias are assumed to be the result of membrane depolarization, however, the exact mechanism of depolarization during acidosis ...
Omar Ababneh +10 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
AggregateCilia and their nucleating bodies, centrioles, are enigmatic structures in cell biology. The immotile primary cilium, lacking the motor proteins required to drive fluid flow, was widely considered vestigial throughout the 20th century; in sharp contrast,
Daniel L. Bilezikian +5 more
doaj +1 more source
Plant quantum biology: The quantum dimension of plant responses to stress
Plant StressThe intricate interplay of quantum coherence, entanglement, radical pair mechanisms, and tunneling, suggests that plants operate at a level of sophistication beyond classical expectations.
Massimo E. Maffei
doaj +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Quantum biology: From mechanisms to medicine
Clinical and Translational MedicineBackground Quantum biology explores how quantum mechanical phenomena—including coherence, tunneling, superposition, and spin dynamics—contribute to biological function.
Ji‐Yong Sung, Jae‐Ho Cheong
doaj +1 more source
Magnetic Field Intervention Enhances Cellular Migration Rates in Biological Scaffolds
Bioengineering, 2023 The impact of magnetic fields on cellular function is diverse but can be described at least in part by the radical pair mechanism (RPM), where magnetic field intervention alters reactive oxygen species (ROS) populations and downstream cellular signaling.
Amy M. Vecheck +3 more
doaj +1 more source