Results 21 to 30 of about 76,256 (108)

Synthesis, Biological Activity, and Molecular Dynamics Simulations of LNA‐Charge Neutral Linkages for Enhanced Splice‐Switching Antisense Oligonucleotides

Angewandte Chemie, Volume 137, Issue 46, November 10, 2025.
Splice‐switching oligonucleotides are used to treat severe genetic conditions including Duchenne Muscular Dystrophy, but new chemistries are urgently required to improve their efficacy. In this work locked nucleic acid (LNA) is coupled to different charge neutral DNA backbones which are studied by structural, thermodynamic, and biological methods.
Alice Kennett, Lillian Lie, Martin Flerin, Belma Zengin Kurt, Ysobel R. Baker, Alyssa C. Hill, Abinaya Ramesh, Matthew J.A. Wood, Debashis Dhara, Afaf H. El‐Sagheer, Fernanda Duarte, Tom Brown   +11 more
wiley   +2 more sources

Operational Axioms for Quantum Mechanics [PDF]

, 2006
The mathematical formulation of Quantum Mechanics in terms of complex Hilbert space is derived for finite dimensions, starting from a general definition of "physical experiment" and from five simple Postulates concerning "experimental accessibility and ...
D'Ariano, Giacomo Mauro
core   +5 more sources

Do quantum states evolve? Apropos of Marchildon's remarks

, 2003
Marchildon's (favorable) assessment (quant-ph/0303170, to appear in Found. Phys.) of the Pondicherry interpretation of quantum mechanics raises several issues, which are addressed.
Mohrhoff, Ulrich
core   +1 more source

Topological Wilson-loop area law manifested using a superposition of loops

, 2013
We introduce a new topological effect involving interference of two meson loops, manifesting a path-independent topological area dependence. The effect also draws a connection between quark confinement, Wilson-loops and topological interference effects ...
Benni Reznik, Boada O, Erez Zohar, Lewenstein M, Mazza L, Polyakov A M, Tagliacozzo L Celi A Orland P Lewenstein M, Zohar E Cirac I J Reznik B   +7 more
core   +1 more source

Flow Cytometry: Advances, Challenges and Trends

BioEssays, EarlyView.
Recent advances in flow cytometry span hardware, data processing, and AI‐driven analytics. Emerging modalitiesincluding spectral, imaging, mass, and nano/EV cytometryenable higher‐parameter and small‐particle detection. Integrated machine learning drives a shift from manual gating toward automated multi‐omics workflows.
J. Paul Robinson, Grzegorz B. Gmyrek, Bartek Rajwa   +2 more
wiley   +1 more source

Quantum Mechanics and Discrete Time from "Timeless" Classical Dynamics

, 2003
We study classical Hamiltonian systems in which the intrinsic proper time evolution parameter is related through a probability distribution to the physical time, which is assumed to be discrete.
Elze, H. -T.
core   +1 more source

Aluminum versus Gallium: Differences in Bis(bis(trimethylsilyl)methyl) Element Halides, Hydrides, and Oxygen‐Bridged E/P Frustrated Lewis Pairs

ChemistryEurope, EarlyView.
Reacting Bis2GaBr (Bis = CH(SiMe3)2) with Bis2AlH selectively yields Bis2GaH, a monomeric hydride in solution, characterized by diffusion ordered spectroscopy NMR, infrared spectroscopy and indirectly via hydrogallation. A one‐pot route enables frustrated Lewis pairs Bis2EOPtBu2 (E = Al, Ga), with the gallium analog splitting H2 and showing a dynamic ...
Julian Buth, Maximilian J. Klingsiek, Yury V. Vishnevskiy, Andreas Mix, Jan-Hendrik Lamm, Beate Neumann, Hans-Georg Stammler, Norbert Werner Mitzel   +7 more
wiley   +1 more source

Experimental estimation of the dimension of classical and quantum systems

, 2011
An overwhelming majority of experiments in classical and quantum physics make a priori assumptions about the dimension of the system under consideration.
A Acín, A Mair, AC Dada, Antonio Acín, B Lanyon, C-E Bardyn, D Mayers, D Pérez-García, G Molina-Terriza, G Molina-Terriza, G Molina-Terriza, H-W Li, J Briët, J-D Bancal, Juan P. Torres, K Pál, L Allen, M Junge, M Junge, M Pawlowski, Martin Hendrych, Michal Mičuda, MM Wolf, N Brunner, Nicolas Brunner, NK Langford, R Gallego, R Rabelo, Rodrigo Gallego, RW Spekkens, S Massar, S Wehner, T Vértesi, T Vértesi   +33 more
core   +1 more source

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

Quantum Diagonalization Method in the Tavis-Cummings Model

, 2004
To obtain the explicit form of evolution operator in the Tavis-Cummings model we must calculate the term ${e}^{-itg(S_{+}\otimes a+S_{-}\otimes a^{\dagger})}$ explicitly which is very hard.
Fujii, Kazuyuki, Higashida, Kyoko, Kato, Ryosuke, Suzuki, Tatsuo, Wada, Yukako   +4 more
core   +3 more sources