Translation‐Promoting Effects of RNA Template Overhangs in the Absence of Ribosomes
Ribosome‐free translation of an RNA sequence into a peptide sequence can be controlled by the folding of the template strand. Overhang sequences forming a triplex structure with the templating region and the peptidoyl RNA in pH‐dependent manner increase yields up to 40‐fold through entropic effects and mixed anhydride formation, allowing for controlled,
Nikolaos Giannakopoulos +2 more
wiley +1 more source
7‐O‐, 9‐O‐, and 7,9‐di‐O‐acetylated GD3 gangliosides can be prepared by chemical assembly of a tetrasaccharide as α‐glycosyl fluoride that is coupled to sphingosine using a glycosynthase, followed by O‐acetyl editing by coronaviral hemagglutinin‐esterases (HEs).
Zhiyong Zhang +5 more
wiley +1 more source
Triplet RNA Lipid Nanoparticles for Locoregional Cancer Immunotherapy
LNPs deliver the immunoadjuvant pIpC into tumors to activate local cells. After activation, additional RNA (siRNA or mRNA) can modulate immune pathways by suppressing immunoinhibitory targets or inducing immunostimulatory ones. This coordinated “triplet RNA” approach may enhance immune activation within the tumor microenvironment.
Adam A. Walters +8 more
wiley +1 more source
Optimizing the localization precision in coherent scattering microscopy using structured light
Abstract We employ the concept of quantum Fisher information to optimize the focused excitation fields in coherent scattering microscopy. Our optimization goal is to achieve the best possible localization precision for small scatterers located above a glass coverslip, while keeping the intensity of the total incoming excitation fields fixed.
Ulrich Hohenester +4 more
wiley +1 more source
Molecular basis for bacterial N-glycosylation by a soluble HMW1C-like N-glycosyltransferase. [PDF]
Piniello B +11 more
europepmc +1 more source
Novel (Phenothiazinyl)Vinyl-Pyridinium Dyes and Their Potential Applications as Cellular Staining Agents. [PDF]
Stoean B +13 more
europepmc +1 more source
A microfluidic biosensor architecture for the rapid detection of COVID-19. [PDF]
Muhsin SA +13 more
europepmc +1 more source
Screening and characterisation of CdTe/CdS quantum dot-binding peptides for material surface functionalisation. [PDF]
Suwatthanarak T +7 more
europepmc +1 more source
Toward Next Generation Lateral Flow Assays: Integration of Nanomaterials. [PDF]
Sena-Torralba A +4 more
europepmc +1 more source
Development of New Natural Lipid-Based Nanoparticles Loaded with Aluminum-Phthalocyanine for Photodynamic Therapy against Melanoma. [PDF]
Mello VC +20 more
europepmc +1 more source

