Results 41 to 50 of about 1,982,675 (253)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The study of quantum spectral imaging

, 2017
At the beginning of 2001, Professor Siwen Bi first proposed the new direction of quantum remote sensing at home and abroad. Based on the research of fundamental theory and information mechanism of quantum remote sensing, a new concept of quantum ...
Wang, Li, Wangyun Liu, Bi, SW, Liu, Wangyun, Lu Chen, Lu, Baozhu, Wang, Guoguo, Guoguo Wang, Li Wang, Xibo Dou, Dou, Xibo, Chen, Lu, Baozhu Lu, Chen, Mingrui, Bi, Siwen, Siwen Bi, Mingrui Chen   +16 more
core   +1 more source

Mass sensing by quantum criticality [PDF]

Optics Letters, 2019
Mass sensing connects the mass variation to a frequency shift of a mechanical oscillator, whose limitation is determined by its mechanical frequency resolution. Here we propose a method to enlarge a minute mechanical frequency shift, which is smaller than the linewidth of the mechanical oscillator, into a huge frequency shift of the normal mode ...
Bin, Shang-Wu, Lü, Xin-You, Yin, Tai-Shuang, Zhu, Gui-Lei, Bin, Qian, Wu, Ying   +5 more
openaire   +3 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

In situ upgrade of quantum simulators to universal computers [PDF]

, 2018
Quantum simulators, machines that can replicate the dynamics of quantum systems, are being built as useful devices and are seen as a stepping stone to universal quantum computers.
Benjamin Dive, Alexander Pitchford, Burgarth, Daniel, Florian Mintert, Daniel Burgarth, Dive, B, Mintert, Florian, Pitchford, Alexander   +7 more
core   +1 more source

Quantum vibropolaritonic sensing

Science Advances
Vibrational spectroscopies are pivotal in analytical methods and biomedical diagnostics owing to their singular ability to provide molecular specificity. However, they are intrinsically limited by weak light-matter interactions and vulnerability to intensity fluctuations and spectral interference.
Peng Zheng, Steve Semancik, Ishan Barman
openaire   +2 more sources

Optimal Generators for Quantum Sensing

Physical Review Letters, 2023
We propose a computationally efficient method to derive the unitary evolution that a quantum state is most sensitive to. This allows one to determine the optimal use of an entangled state for quantum sensing, even in complex systems where intuition from canonical squeezing examples breaks down.
Jarrod T. Reilly, John Drew Wilson, Simon B. Jäger, Christopher Wilson, Murray J. Holland   +4 more
openaire   +3 more sources

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Quantum Radar: State of the Art and Potential of a Newly-Born Remote Sensing Technology [PDF]

, 2019
Quantum technology has already been introduced in many fields, like information processing and communications, and it can potentially change our approach to remote sensing in the microwave and millimeter-wave domain,
A. Bogoni, G. Serafino, FS Cataliotti, P De Natale, M De Rosa, A Masini, S Avino, I Ricciardi, G Gagliardi, N Fabbri   +9 more
core   +1 more source