Results 161 to 170 of about 1,094,572 (279)

Supramolecular Mechanophore Additives Enable Mechanochromic Hydrogels

open access: yesAngewandte Chemie, EarlyView.
A supramolecular loop‐forming mechanophore featuring a quencher and an emitter is incorporated as a water‐soluble macromolecular additive into hydrogels. In the stress‐free state, intramolecular charge‐transfer interactions fold the loop and quench fluorescence.
Iulia Scarlat   +2 more
wiley   +2 more sources

Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators

open access: yesAngewandte Chemie, EarlyView.
The paper describes the serendipitous discovery of chemical manipulation allowing the activator‐to‐inhibitor switching in Kv7.2 channel modulators. The molecular determinants driving this switch have been rationalized by multidisciplinary investigation encompassing synthetic and analytical chemistry, in silico methods, cryo‐EM analysis ...
Tania Ciaglia   +20 more
wiley   +2 more sources

Polymer Brushes Govern Defect‐Selective Oxidative Etching of Penta‐Twinned Gold Nanorods

open access: yesAngewandte Chemie, EarlyView.
Polymer brushes act as active interfacial regulators of oxidative etching, directing it to crystallographic defects. In penta‐twinned gold nanorods, defect–ligand interplay localizes etching to defect regions and induces surface corrugations on the long nanorod sides. This work establishes a framework for programmable nanoengineering of the surfaces of
Tianyi Wu   +9 more
wiley   +2 more sources

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

open access: yesAngewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster   +13 more
wiley   +2 more sources

Observation of quantum superposition of topological defects in a trapped-ion quantum simulator. [PDF]

open access: yesSci Adv
Cheng ZJ   +10 more
europepmc   +1 more source

Macroscopicity of quantum superposition

open access: yes
In this paper, we define a universal measure of macroscopicity $\beta$ in the form of,  experimentally observed coherence time/ characteristic time required to repeatably distinguish the components of a quantum superposition state, to divide the quantum/classical (Q-C) boundary.
openaire   +2 more sources

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