Results 221 to 230 of about 216,809 (266)

Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming

Advanced Science, EarlyView.
Single‐cell profiling of TF‐induced forward programming versus stepwise dual‐SMAD differentiation reveals that divergent trajectories set the pace of neurogenesis. OLIG TFs advance cell‐cycle exit via NOTCH modulation, while NEUROD2 later accelerates maturation. The study elucidates transcriptional mechanisms governing differentiation timing, providing
Lingling Zhu, Weiguang Wang, Jian Zhang, Lei Liu, Minpeng Huang, Lei Diao, Shuang Feng, Qiong Yang, Hao Qiu, Bing Pan, Renee A Reijo Pera, Ji Liu, Ninuo Xia, Fang Fang   +13 more
wiley   +1 more source

Trends of ciprofloxacin use in Kazakhstan, impacts of COVID-19, and strategies for AMR control. [PDF]

Sci Rep
Kussainova A, Kassym L, Aljofan M, Akhmetova K, Derbissalina G, Bekbergenova Z, Uzbekova S, Botabayeva A, Semenova Y.   +8 more
europepmc   +1 more source

Rapid Microfluidic Drug Sensitivity Testing Within 5 Days Using Minimal Clinical Tumor Samples

Advanced Science, EarlyView.
This study develops the air‐punched fabrication approach for nanoliter‐scale microcavity arrays with ultra‐smooth microcavity surfaces, with which rapid formation and 3D culture of tumor cell spheroids from small numbers of cell samples, as well as high‐throughput drug sensitivity testing can be achieved within 5 days.
Yi‐Xue Chen, Yi Zhang, Yu‐Jie Yan, Meng‐Ting Zhang, Jian‐Bo Chen, Yi‐Rong Jiang, Jie Wu, Hui‐Feng Wang, Jian‐Zhang Pan, Zhi‐Gang Chen, Jian Huang, Qun Fang   +11 more
wiley   +1 more source

Trends in antibiotic use in long-term care hospitals during the COVID-19 pandemic: a nationwide cohort study during 2020 and 2023. [PDF]

BMC Infect Dis
Kim YC, Chae J, Shin J, Kim Y, Lee E, Kim DS.   +5 more
europepmc   +1 more source

Unique Aerofoil‐Structured Microfluidics for High Throughput Lipid Nanoparticle Formulation Screening and Scale‐up

Advanced Science, EarlyView.
This study presents aerofoiled microfluidic structures optimized for efficient mixing and lipid nanoparticle (LNP) formation across broad flow rates. Based on this design, two dedicated systems are introduced: MiNANO‐form for high‐throughput formulation screening and MiNANO‐scale for continuous large‐scale production, enabling reproducible, high ...
Dongsheng Liu, Mingzhi Yu, Yuguo Zhang, Allen Mathew, Tianyu Guan, Liang Yao, Xianqing Wang, Wenxin Wang, Nan Zhang   +8 more
wiley   +1 more source

Impact of post-admission changes in potentially inappropriate medication use on risk of subsequent hospitalization among nursing home residents. [PDF]

Front Pharmacol
Zhao J, Chae H, Ah YM, Jun K, Lee JY.
europepmc   +1 more source

WAGE DIFFERENTIALS IN THE CZECH AGRICULTURAL SECTOR IN THE PERIOD OF THE 1ST QUARTER 2000 TO THE 3RD QUARTER 2012 AND LABOR PRODUCTIVITY

, 2014
Marta Gryčová
openalex   +1 more source

Correlative Imaging Platform Linking Taste Cell Function to Molecular Identity

Advanced Science, EarlyView.
A correlative imaging platform is developed to study how individual taste cells respond to different taste qualities. By linking cellular activity with molecular identity and environmental context, dual‐tuned taste cells capable of detecting both sweet and umami stimuli are identified.
Sungho Lee, Minjae Kim, Gha Yeon Park, Jubeen Yoon, Kunyoo Shin, Chang Ho Sohn, Myunghwan Choi   +6 more
wiley   +1 more source

Prescription rates in different groups of outpatients with covid-19 and other acute respiratory infections: comparative observational study based on German routine data. [PDF]

BMJ Med
Paschke LM, Klimke K, Below M.
europepmc   +1 more source

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

Advanced Science, EarlyView.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei, Junbin Chen, Chuang Liu, DanDan Liu, Meida Du, Shengfeng He, Wenyu Cheng, Vijai Bhadauria, You‐Liang Peng, Wangsheng Zhu   +9 more
wiley   +1 more source