Results 241 to 250 of about 4,012 (254)
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Molecular Quasi-Species in Hopfield Replication Landscapes
1993Twenty years ago Eigen1 proposed a model which, in the mathematical formulation given by Eigen and Schuster2, links the dynamics of population genetic in biological systems with the dynamics of chemical reactions opening the field of molecular evolution. In its simplest realization the model describes a system of aperiodic polymers with a fixed number,
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Quasi specie virale: modello matematico e considerazioni biologiche [PDF]
, 1998 Il modello della “quasi-specie virale” (Eigen, Naturwissenschaften Vol.58: 465, 1971) è stato molto spesso citato, ma la condizione Q·S31, dove Q è la fedeltà replicativa ed S è il coefficiente di selezione su cui è basato non è sufficientemente chiara.
VALANDRO, LUCA +2 more
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Journal of Theoretical Biology, 1998
Yeast aminoacyl-tRNA synthetases act in a multi-step process when recognizing their cognate amino acids; this identification event includes "physical" binding and "chemical" proof-reading steps. However, the various enzymes use these single steps at different degrees, and their specificities with regard to the 20 naturally occurring amino acids deviate
W, Freist +3 more
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Yeast aminoacyl-tRNA synthetases act in a multi-step process when recognizing their cognate amino acids; this identification event includes "physical" binding and "chemical" proof-reading steps. However, the various enzymes use these single steps at different degrees, and their specificities with regard to the 20 naturally occurring amino acids deviate
W, Freist +3 more
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Quasi-species model for host-parasite coevolution with a frequency-dependent fitness landscape
Journal of the Korean Physical Society, 2014We investigate the host-parasite coevolution by using the quasi-species model with a frequencydependent fitness landscape. We propose a quasi-species model for the host-parasite coevolution and find the phase diagram for a given set of dynamics parameters by means of a linear stability analysis and numerical solutions.
Yung-Gyung Kang, Jeong-Man Park
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Uniqueness of the fixed point for the quasi-species model under changing environments
Journal of the Korean Physical Society, 2010We investigate the uniqueness of the stable fixed point of the quasi-species models: the Eigen model and the Parallel Mutation-Selection model. Under changing environments with a sharp-peak fitness function where the fitness peak oscillates periodically, we use the Perron-Frobenius theorem to show that the stable fixed point must be unique in those ...
Jeong-Man Park, Mark Ancliff
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Molecular Quasi-species and Spin Glasses
1994The equations describing how the composition of a solution of self replicating (RNA-like) molecules, introduced by Eigen, were cast in a form treatable by equilibrium statistical mechanics methods by Leuthausser. Since the reproduction frequency ("fitness") exhibits in principle many optima as a function of the primary molecular structure (nucleotide ...
Silvio Franz +2 more
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Evolution of hepatitis B genotype C viral quasi-species during hepatitis B e antigen seroconversion
Journal of Hepatology, 2011Although the evolution of viral quasi-species may be related to the pathological status of disease, little is known about this phenomenon in hepatitis B, particularly with respect to hepatitis B e antigen (HBeAg) seroconversion.Nucleotide sequences of the hepatitis B virus (HBV) X/precore/core region was analyzed at five time-points in four groups of ...
Shuang, Wu +9 more
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Polymers in a Random Environment and Molecular Quasi-Species
1994The quasi-species model was introduced in 1971 by Manfred Eigen1 to describe evolving populations of self-reproducing (RNA-like) molecules. It lies at the basis of the theory of the origin of biological organization, and in particular of the hypercycle theory, developed by Eigen and P. Schuster2. It may be cast in the following form.
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The Journal of Physical Chemistry, 1988
Eigen, M., McCaskill, J., Schuster, P.
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Eigen, M., McCaskill, J., Schuster, P.
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