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Polymers in a Random Environment and Molecular Quasi-Species
1994The quasi-species model was introduced in 1971 by Manfred Eigen1 to describe evolving populations of self-reproducing (RNA-like) molecules. It lies at the basis of the theory of the origin of biological organization, and in particular of the hypercycle theory, developed by Eigen and P. Schuster2. It may be cast in the following form.
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Journal of Theoretical Biology, 1998
Yeast aminoacyl-tRNA synthetases act in a multi-step process when recognizing their cognate amino acids; this identification event includes "physical" binding and "chemical" proof-reading steps. However, the various enzymes use these single steps at different degrees, and their specificities with regard to the 20 naturally occurring amino acids deviate
Friedrich Cramer +3 more
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Yeast aminoacyl-tRNA synthetases act in a multi-step process when recognizing their cognate amino acids; this identification event includes "physical" binding and "chemical" proof-reading steps. However, the various enzymes use these single steps at different degrees, and their specificities with regard to the 20 naturally occurring amino acids deviate
Friedrich Cramer +3 more
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Molecular Quasi-Species in Hopfield Replication Landscapes
1993Twenty years ago Eigen1 proposed a model which, in the mathematical formulation given by Eigen and Schuster2, links the dynamics of population genetic in biological systems with the dynamics of chemical reactions opening the field of molecular evolution. In its simplest realization the model describes a system of aperiodic polymers with a fixed number,
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Molecular Quasi-species and Spin Glasses
1994The equations describing how the composition of a solution of self replicating (RNA-like) molecules, introduced by Eigen, were cast in a form treatable by equilibrium statistical mechanics methods by Leuthausser. Since the reproduction frequency ("fitness") exhibits in principle many optima as a function of the primary molecular structure (nucleotide ...
Silvio Franz +2 more
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Clinical Infectious Diseases, 2002
Phenotypic and molecular studies were conducted to characterize multiple influenza A isolates recovered from an immunocompromised patient who died of viral and fungal pneumonitis.
G. Boivin, N. Goyette, H. Bernatchez
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Phenotypic and molecular studies were conducted to characterize multiple influenza A isolates recovered from an immunocompromised patient who died of viral and fungal pneumonitis.
G. Boivin, N. Goyette, H. Bernatchez
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Quasi-species model for host-parasite coevolution with a frequency-dependent fitness landscape
Journal of the Korean Physical Society, 2014We investigate the host-parasite coevolution by using the quasi-species model with a frequencydependent fitness landscape. We propose a quasi-species model for the host-parasite coevolution and find the phase diagram for a given set of dynamics parameters by means of a linear stability analysis and numerical solutions.
Jeong-Man Park, Yung-Gyung Kang
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Molecular evolution and quasi-species
1994Abstract As our first model of a primitive biochemical system, we will examine a model originally proposed by Manfred Eigen in 1971, and developed further by Eigen in collaboration with Peter Schuster in 1977. The model assumes the existence of molecules of an indeterminate structure which have the ability to replicate themselves without
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