Results 61 to 70 of about 4,012 (254)

Hamiltonian model for multidimensional epistasis [PDF]

, 2002
We propose and solve a Hamiltonian model for multidimensional epistastatic interactions between beneficial mutations. The model is able to give rise either to a phase transition between two equilibrium states, without any coexistence, or exhibits a state
AYŞE ERZAN, Bakk A., SEHER ÖZÇELIK, Smith J. M.   +3 more
core   +2 more sources

Multivariate-activity mining for molecular quasi-species in a glutathione transferase mutant library [PDF]

Protein Engineering, Design and Selection, 2007
A library of recombinant glutathione transferases (GSTs) generated by shuffling of DNA encoding human GST M1-1 and GST M2-2 was screened with eight alternative substrates, and the activities were subjected to multivariate analysis. Assays were made in lysates of bacteria in which the GST variants had been expressed.
Sanela, Kurtovic, Arna, Runarsdottir, Lars O, Emrén, Anna-Karin, Larsson, Bengt, Mannervik   +4 more
openaire   +2 more sources

Advancing Electronic Application of Coordination Solids: Enhancing Electron Transport and Device Integration via Surface‐Mounted MOFs (SURMOFs)

Advanced Functional Materials, EarlyView.
The layer‐by‐layer (LbL) assembly of coordination solids, enabled by the surface‐mounted metal‐organic framework (SURMOF) platform, is on the cusp of generating the organic counterpart of the epitaxy of inorganics. The programmable and sequential SURMOF protocol, optimized by machine learning (ML), is suited for accessing high‐quality thin films of ...
Zhengtao Xu, Christof Wöll, Stefan Bräse   +2 more
wiley   +1 more source

Dynamic fitness landscapes: Expansions for small mutation rates [PDF]

, 2000
We study the evolution of asexual microorganisms with small mutation rate in fluctuating environments, and develop techniques that allow us to expand the formal solution of the evolution equations to first order in the mutation rate.
Demetrius, Drake, Eigen, Eigen, Eigen, Jones, Jones, Leuthäusser, Levin, Nilsson, Ronnewinkel, Swetina, Tarazona, Wilke, Yoshimura   +14 more
core   +3 more sources

Human Immunodeficiency Virus Type 1 Quasi Species That Rebound after Discontinuation of Highly Active Antiretroviral Therapy Are Similar to the Viral Quasi Species Present before Initiation of Therapy [PDF]

The Journal of Infectious Diseases, 2001
In an effort to identify the sources of the viruses that emerge after discontinuation of therapy, analyses of human immunodeficiency virus (HIV) quasi species were done for 3 patients with sustained levels of HIV RNA of
H, Imamichi, K A, Crandall, V, Natarajan, M K, Jiang, R L, Dewar, S, Berg, A, Gaddam, M, Bosche, J A, Metcalf, R T, Davey , H C, Lane   +10 more
openaire   +2 more sources

Copper‐based Materials for Photo and Electrocatalytic Process: Advancing Renewable Energy and Environmental Applications

Advanced Functional Materials, EarlyView.
Cu‐based catalysts as a cornerstone in advancing sustainable energy technologies are fully reviewed in this manuscript, highlighting their potential in photo‐ and electrocatalysis. It includes metallic copper, copper oxides, copper sulfides, copper halide perovskites, copper‐based metal–organic frameworks (MOFs), and covalent organic frameworks (COFs),
Jéssica C. de Almeida, Yanjie Wang, Thais A. Rodrigues, Paulo H. H. Nunes, Vagner R. de Mendonça, Paulo H. E. Falsetti, Leticia V. Savazi, Tao He, Alexandra V. Bardakova, Aida V. Rudakova, Jie Tian, Alexei V. Emeline, Osmando F. Lopes, Antonio Otavio T. Patrocínio, Jia Hong Pan, Caue Ribeiro, Detlef W. Bahnemann   +16 more
wiley   +1 more source

Virus Replication as a Phenotypic Version of Polynucleotide Evolution

, 2013
In this paper we revisit and adapt to viral evolution an approach based on the theory of branching process advanced by Demetrius, Schuster and Sigmund ("Polynucleotide evolution and branching processes", Bull. Math. Biol.
A. Eyre-Walker, A. Kowald, A. Timm, C. Escarmís, C. J. Thompson, C. Meyer, C. O. Wilke, C. O. Wilke, D. A. Steinhauer, D. R. Rokyta, Diogo Castro, E. Domingo, E. Domingo, E. Lázaro, F. Antoneli, F. Antoneli, F. Gantmacher, Fernando Antoneli, Francisco Bosco, H. A. Orr, H. W. Watson, I. Leuthäusser, J. A. Capitán, J. A. Cuesta, J. A. Cuesta, J. Aguirre, J. Aguirre, J. H. Wilkinson, J. Hermisson, J. J. Bull, J. J. Bull, J. J. Bull, J. Swetina, K. B. Athreya, K. Dietz, L. Demetrius, L. Demetrius, Luiz Mario Janini, M. Delbrück, M. Eigen, M. Eigen, M. Imhof, M. Jiřina, M. Kimmel, M. Parera, M. Ziehe, P. Carrasco, P. D. Keightley, P. Domingo-Calap, P. Jagers, R. Forster, R. M. Gray, R. Miralles, R. Sanjuán, S. C. Manrubia, S. Crotty, S. F. Elena, S. F. Elena, S. Ojosnegros, S. Ojosnegros, T. G. Kurtz, T. Harris, U. Grenander, W. Feller, Y. Zhu   +64 more
core   +1 more source

Fluctuation induces evolutionary branching in a modeled microbial ecosystem [PDF]

, 2007
The impact of environmental fluctuation on species diversity is studied with a model of the evolutionary ecology of microorganisms. We show that environmental fluctuation induces evolutionary branching and assures the consequential coexistence of ...
A White, CS Holling, CV Rao, D Tilman, E Litchman, GF Gause, HL Smith, J Huisman, J Monod, JH Connell, JM Cushing, K Kaneko, K Kaneko, K Kovárová-Kovar, M Eigen, M Huston, Mark Isalan, Masashi Tachikawa, P Chesson, R Armstrong, R MacArthur, SAH Geritz, SAH Geritz, SAH Geritz, T Shibata, T Yanagida, U Dieckmann   +26 more
core   +5 more sources

Copper Doping Enhances the Activity and Selectivity of Atomically Precise Ag44 Nanoclusters for Photocatalytic CO2 Reduction

Advanced Functional Materials, EarlyView.
By a simple anti‐Galvanic reaction, up to six copper atoms could be preferably doped into the Ag2(SR)5 staple motifs and Ag20 dodecahedral shell of an atomically precise Ag44(SR)30 nanocluster. When anatase TiO2 is used as substrate, the (AgCu)44/TiO2 photocatalyst exhibited much improved activity in photocatalytic CO2 reduction compared to Ag44/TiO2 ...
Ye Liu, Xi Zheng, Xiufan Liu, Tengyuan Gao, Nicola Pinna, Yu Wang   +5 more
wiley   +1 more source

Resistance of Hepatitis C Virus to Inhibitors: Complexity and Clinical Implications

Viruses, 2015
Selection of inhibitor-resistant viral mutants is universal for viruses that display quasi-species dynamics, and hepatitis C virus (HCV) is no exception.
Celia Perales, Josep Quer, Josep Gregori, Juan Ignacio Esteban, Esteban Domingo   +4 more
doaj   +1 more source