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Virology, 2015 New generation sequencing is greatly expanding the capacity to examine the composition of mutant spectra of viral quasispecies in infected cells and host organisms. Here we review recent progress in the understanding of quasispecies dynamics, notably the occurrence of intra-mutant spectrum interactions, and implications of fitness landscapes for virus ...
Raul Andino, Esteban Domingo
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Viral Quasispecies Evolution [PDF]
Microbiology and Molecular Biology Reviews, 2012 SUMMARYEvolution of RNA viruses occurs through disequilibria of collections of closely related mutant spectra or mutant clouds termed viral quasispecies. Here we review the origin of the quasispecies concept and some biological implications of quasispecies dynamics.
Esteban Domingo +2 more
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Viral quasispecies complexity measures
Virology, 2016 Mutant spectrum dynamics (changes in the related mutants that compose viral populations) has a decisive impact on virus behavior. The several platforms of next generation sequencing (NGS) to study viral quasispecies offer a magnifying glass to study viral quasispecies complexity.
Josep Gregori Font +2 more
exaly +3 more sources
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European Biophysics Journal, 2018
Quasispecies theory has been instrumental in the understanding of RNA virus population dynamics because it considered for the first time mutation as an integral part of the replication process. The key influences of quasispecies theory on experimental virology have been: (1) to disclose the mutant spectrum nature of viral populations and to evaluate ...
Esteban Domingo, Celia Perales
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Quasispecies theory has been instrumental in the understanding of RNA virus population dynamics because it considered for the first time mutation as an integral part of the replication process. The key influences of quasispecies theory on experimental virology have been: (1) to disclose the mutant spectrum nature of viral populations and to evaluate ...
Esteban Domingo, Celia Perales
openaire +2 more sources
The Science of Nature
The quasispecies theory is a helpful concept in the explanation of RNA virus evolution and behaviour, with a relevant impact on methods used to fight viral diseases. It has undergone some adaptations to integrate new empirical data, especially the non-deterministic nature of mutagenesis, and the variety of behavioural motifs in cooperation, competition,
Esteban, Domingo, Guenther, Witzany
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The quasispecies theory is a helpful concept in the explanation of RNA virus evolution and behaviour, with a relevant impact on methods used to fight viral diseases. It has undergone some adaptations to integrate new empirical data, especially the non-deterministic nature of mutagenesis, and the variety of behavioural motifs in cooperation, competition,
Esteban, Domingo, Guenther, Witzany
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Hepatitis C viral quasispecies
Journal of Viral Hepatitis, 1999Analysing significant numbers of cDNA clones of the hepatitis C virus (HCV) from single isolates provides unquestionable proof that the viral genome cannot be defined by a single sequence, but rather by a population of variant sequences closely related to one another.
J, Gómez +4 more
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2006
The concept of the quasispecies as a society formed from a clone of an asexually reproducing organism is reviewed. A broad spectrum of mutants is generated that compete one with another. Eventually a steady state is formed where each mutant type is represented according to its fitness and its formation by mutation.
Biebricher, C., Eigen, M.
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The concept of the quasispecies as a society formed from a clone of an asexually reproducing organism is reviewed. A broad spectrum of mutants is generated that compete one with another. Eventually a steady state is formed where each mutant type is represented according to its fitness and its formation by mutation.
Biebricher, C., Eigen, M.
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Theoretical Models of Generalized Quasispecies
2015Theoretical modeling of quasispecies has progressed in several directions. In this chapter, we review the works of Emmanuel Tannenbaum, who, together with Eugene Shakhnovich at Harvard University and later with colleagues and students at Ben-Gurion University in Beersheva, implemented one of the more useful approaches, by progressively setting up ...
Nathaniel, Wagner +2 more
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Quasispecies in Time-Dependent Environments
2006In recent years, quasispecies theory in time-dependent (that is, dynamically changing) environments has made dramatic progress. Several groups have addressed questions such as how the time scale of the changes affect viral adaptation and quasispecies formation, how environmental changes affect the optimal mutation rate, or how virus and host co-evolve.
Wilke, C. O. +2 more
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Isomorphism of Quasispecies and Percolation Models
Journal of Theoretical Biology, 2000Population dynamics of tRNA-like macromolecules and viruses have been interpreted by Eigen (1971, Naturwissenschaften58, 465-526) on the basis of the "quasispecies" model. The present paper contains a qualitative analysis of the similarities between Eigen's quasispecies model and percolation models.
VALANDRO, LUCA +3 more
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