Results 61 to 70 of about 180 (108)

Ailanthone: a new potential drug for castration-resistant prostate cancer. [PDF]

Chin J Cancer, 2017
Peng S, Yi Z, Liu M.
europepmc   +1 more source

Targeting Trop2 by Bruceine D suppresses breast cancer metastasis by blocking Trop2/β-catenin positive feedback loop. [PDF]

J Adv Res
Tang W, Hu Y, Tu K, Gong Z, Zhu M, Yang T, Sarwar A, Dai B, Zhang D, Zhan Y, Zhang Y.   +10 more
europepmc   +1 more source

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On the reduction of quassin

Tetrahedron, 1987
Abstract The reduction of quassin ( 1a ) with sodium borohydride in the presence of alkali was investigated. The process appeared to be regio- and stereo-selective leading to 2a , which was utilized for the preparation of 2-epi-castelanolide-methylether ( 4a ).
CECCHERELLI, Paolo, CURINI, Massimo, M. DIAMANTINI, MARCOTULLIO, Maria Carla, GRANDOLINI, Giuliano   +4 more
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Quassin and Neoquassin

Tetrahedron, 1961
Abstract Structure XIX (R1 = H; R2 = CH3) was derived for quassin on the basis of extensive chemical and physical evidence.
Z. Valenta, S. Papadopoulos, C. Podešva
openaire   +1 more source

Quassin

Australian Journal of Chemistry, 1962
Nuclear magnetic resonance evidence and additional chemical evidence are reported which supports structure (II) for quassin. A table of the N.M.R. assignments for quassin and four derivatives is included.
Carman, R. M., Ward, A. D.
openaire   +3 more sources

The stereochemistry of quassin

Tetrahedron, 1962
Abstract The relative configuration of quassin and several of its derivatives has been derived.
Z. Valenta, A.H. Gray, D.E. Orr, S. Papadopoulos, C. Podešva   +4 more
openaire   +1 more source

Total Synthesis of (+)-Quassin

The Journal of Organic Chemistry, 2000
A total synthesis of (+)-quassin from naturally occurring (S)-(+)-carvone is described. The total number of steps was 28, and the overall yield was about 2.6%. The synthetic strategy for the construction of the tetracyclic carbon framework was based on a C-->ABC-->ABCD ring annulation sequence, involving an aldol reaction, an intramolecular Diels-Alder
T K, Shing, Q, Jiang
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Semisynthetic derivatives of quassin

Tetrahedron, 1998
The natural product quassin has been modified in order to produce compounds with potential antimalarial action. The modifications include demethylation, reduction of the keto function, esterification with simple organic acids and - to enhance the uptake through the biological barriers and increase the stability of the compounds - with lipoamino acids.
Thoruwa, C. L., Watt, Robert A., Toth, Istvan, Phillipson, David J.   +3 more
openaire   +2 more sources

On equilibration of quassin and 4-epiquassin

Collection of Czechoslovak Chemical Communications, 1991
Equilibration of quassin and 4-epiquassin is described. Various quassin derivatives are characterized and their relationship to quassin (I) is discussed. A regioselective deprotonation is achieved in quassin and 4-epiquassin (III) by the introduction of a diosphenolate grouping which makes a potentially acidic H-atom unavailable for attack by base.
Nada Stojanac, Zdenek Valenta
openaire   +1 more source

Plasmodium falciparum: In vitro interaction of quassin and neo-quassin with artesunate, a hemisuccinate derivative of artemisinin

Experimental Parasitology, 2010
Quassia amara L. (Family Simaroubaceae) is known to have several medicinal properties including the activity against malaria. An HPLC method was employed for purification of the biologically active quassinoids; quassin (Q) and neo-quassin (NQ), further characterized by MALDI-TOF analyses.
Kirti, Mishra, Dipjyoti, Chakraborty, Amita, Pal, Nrisingha, Dey   +3 more
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