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Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source
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Computing Partial Quaternion Eigenpairs with Quaternion Shift

Journal of Scientific Computing, 2023
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Zhigang Jia   +3 more
openaire   +1 more source

Quantum quaternions

Journal of Mathematical Physics, 1992
The notion of quantum quaternions is introduced as a one-parametric quantum deformation of the quaternion algebra. An appriopriate noncommutative differential calculus is developed and the quantum version of the Fueter equation is founded.
MARCHIAFAVA, Stefano, Jakub Rembielinski
openaire   +1 more source

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