Results 271 to 280 of about 57,815 (333)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

A spatio-temporal graph diffusion and federated contrastive learning framework for cross-institutional educational evaluation. [PDF]

Sci Rep
Fang X, Xiao F.
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

A Novel Shallow Neural Network-Augmented Pose Estimator Based on Magneto-Inertial Sensors for Reference-Denied Environments. [PDF]

Sensors (Basel)
Odry A, Sarcevic P, Carbone G, Odry P, Kecskes I.   +4 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Minimal stimulus strategy for diagnosis and treatment of BPPV: a virtual simulation study. [PDF]

Eur Arch Otorhinolaryngol
Li X, Yang R, Zhang Y, Ying Y, Xu X, Gao L, Li Y, Shao Q, Wang W, Sun C, Yang X.   +10 more
europepmc   +1 more source

A novel approach for three-dimensional evaluation of reduction morphology in distal radius fracture. [PDF]

BMC Musculoskelet Disord
Yoshii Y, Eda Y, Asai R, Ikumi A, Totoki Y, Kohyama S, Ogawa T.   +6 more
europepmc   +1 more source

Soft-label guided stacked dual attention network for head pose estimation and its application to classroom gaze analysis. [PDF]

Sci Rep
Xu L, Li Z, Gan Y, Xia H.
europepmc   +1 more source

Two Methods for Superposing the Structures of Like-Molecule Assemblies: Application to Peptide and Protein Oligomers and Aggregates. [PDF]

Molecules
Liwo A, Leśniewski M.
europepmc   +1 more source

Multicooperation of Turtle-inspired amphibious spherical robots. [PDF]

Sci Rep
Zheng L, Ma Y, Yu H, Tang Y.
europepmc   +1 more source