Results 41 to 50 of about 129,667 (316)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Quantum speedup for nonreversible Markov chains

Nature Communications
Quantum algorithms can potentially solve a handful of problems more efficiently than their classical counterparts. In that context, it has been discussed that Markov chains problems could be solved significantly faster using quantum computing.
Baptiste Claudon, Jean-Philip Piquemal, Pierre Monmarché   +2 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Greedy gradient-free adaptive variational quantum algorithms on a noisy intermediate scale quantum computer

Scientific Reports
Hybrid quantum-classical adaptive Variational Quantum Eigensolvers (VQE) hold the potential to outperform classical computing for simulating many-body quantum systems.
César Feniou, Muhammad Hassan, Baptiste Claudon, Axel Courtat, Olivier Adjoua, Yvon Maday, Jean-Philip Piquemal   +6 more
doaj   +1 more source

KUTRITE IN QUANTUM COMPUTATIONS

Современная наука и инновации, 2022
Limitations to the use of information and operation restriction information are a consequence of the physical nature of information. Conservative logic can solve any computable by Church, because with its help it is possible to implement a Turing machine
Svetlana Anatolevna Inozemtseva
doaj  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Shortcut to chemically accurate quantum computing via density-based basis-set correction

Communications Chemistry
Using GPU-accelerated state-vector emulation, we propose to embed a quantum computing ansatz into density-functional theory via density-based basis-set corrections to obtain quantitative quantum-chemistry results on molecules that would otherwise require
Diata Traore, Olivier Adjoua, César Feniou, Ioanna-Maria Lygatsika, Yvon Maday, Evgeny Posenitskiy, Kerstin Hammernik, Alberto Peruzzo, Julien Toulouse, Emmanuel Giner, Jean-Philip Piquemal   +10 more
doaj   +1 more source

FEATURES using reversible logic operations IN MODELING IRREVERSIBLE COMPUTING on the reversibly COMPUTER

Современная наука и инновации, 2022
Information can be recorded in the quantum state and are transmitted via the physical channel. The theory of quantum coding and information theory quantum computing related. In any information system ( classical or quantum) will always contain errors, as
Svetlana Anatolevna Inozemtseva
doaj  

Qubit energy tuner based on single flux quantum circuits

Frontiers in Physics, 2023
A device called the qubit energy tuner (QET), based on single flux quantum (SFQ) circuits, has been proposed for Z control of superconducting qubits. The QET is created by improving flux digital-to-analog converters (flux DACs).
Xiao Geng, Xiao Geng, Kaiyong He, Kaiyong He, Rutian Huang, Rutian Huang, Jianshe Liu, Jianshe Liu, Wei Chen, Wei Chen, Wei Chen   +10 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source