Results 31 to 40 of about 60,971 (294)

To queer or not to queer? – teoria i praktyka tłumaczenia queerowego

Między Oryginałem a Przekładem, 2016
To queer or not to queer? – theoretical framework and practical models of queer translation The purpose of this paper is to present a theoretical framework of a relatively new phenomenon in translation studies that is the queer translation ...
Mateusz Król
doaj   +1 more source

Queering the Gaze: Visualizing Desire in Lacanian Film Theory

Whatever, 2021
Film theorists typically conceptualize the gaze in film in terms of power and mastery. However, using Lacan’s notion of the gaze as the objet petit a, or an unattainable object that provokes desire, this essay examines the objet petit a as the foundation
Grace McNealy
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Tradition and gender

Nordisk Tidskrift för Socioonomastik
Until recently, little attention has been given to men’s surname choices in couples. By analysing men’s narratives, this study investigates the motivations and social implications of their choices.
Line Førre Grønstad
doaj   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

O texto queer

Doxa, 2023
Embora seja um conceito-base no interior do campo transdisciplinar dos estudos queer, sobretudo em sua intersecção com as áreas dedicadas aos estudos da linguagem, o texto queer ainda não possui uma definição exaustiva.
Daniel Padilha Pacheco da Costa, Gustavo Matheus Pires, Rodolfo Gabriel Alves   +2 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Transgender and gender diverse individuals embodying endometriosis: a systematic review

Frontiers in Medicine
BackgroundTransgender and gender diverse (TGD) people embody social and health inequalities that disproportionately affect this community more than the cisgender population. Endometriosis is a chronic condition of the reproductive tract that affects 5–10%
Maddalena Giacomozzi, Maddalena Giacomozzi, Jip Bouwens, Jip Bouwens, Jip Bouwens, Stéphane Guy Aubin, Hester Pastoor, Petra Verdonk, Annemiek Nap   +8 more
doaj   +1 more source

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, EarlyView.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source