Results 31 to 40 of about 24,523 (261)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Sexual and Reproductive Health MattersEndometriosis is a chronic condition characterised by cyclic pain symptoms that often significantly affect health-related quality of life. Predominantly framed as a “woman's condition”, current research overlooks the experiences of transgender and gender-
Maddalena Giacomozzi +5 more
doaj +1 more source
Whatever, 2021 This is part 1 of 6 of the dossier What Do We Talk about when We Talk about Queer Death?, edited by M. Petricola. The contributions collected in this article sit at the crossroads between thanatology and queer theory and tackle questions such as: how can
Patricia MacCormack +5 more
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Genealogy(1) Background: Although culturally grounded health interventions (CGHI) have shown efficacy in improving Indigenous health, few CGHI for Queer and Transgender Pacific Islander (QTPI) communities exist to address their health promotion.
Santino Giovanni Camacho +8 more
doaj +1 more source
Queering Vulnerability: A Layered Bioethical Approach
Suomen Antropologi, 2019 Vulnerability is a concept often used in bioethics. However, it is seldom interrogated from a queer point of view. By queer inquiry, I refer to an umbrella understanding of gender and sexuality as diverse. In this article I discuss lesbian, gay, bisexual,
Tiia Sudenkaarne
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Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Asparkía, 2016 Uno de los escasos libros historiográficos sobre la vida de las mujeres que, huyendo de la represión franquista, migraron y se establecieron en barrios marginales.
Enric Olartecoechea Camprubí
doaj
To queer or not to queer? – teoria i praktyka tłumaczenia queerowego
Między Oryginałem a Przekładem, 2016 To queer or not to queer? – theoretical framework and practical models of queer translation The purpose of this paper is to present a theoretical framework of a relatively new phenomenon in translation studies that is the queer translation ...
Mateusz Król
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Queering the Gaze: Visualizing Desire in Lacanian Film Theory
Whatever, 2021 Film theorists typically conceptualize the gaze in film in terms of power and mastery. However, using Lacan’s notion of the gaze as the objet petit a, or an unattainable object that provokes desire, this essay examines the objet petit a as the foundation
Grace McNealy
doaj +1 more source