Results 31 to 40 of about 131,344 (292)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

1/ Theories and definitions

Whatever, 2021
This is part 1 of 6 of the dossier What Do We Talk about when We Talk about Queer Death?, edited by M. Petricola. The contributions collected in this article sit at the crossroads between thanatology and queer theory and tackle questions such as: how can
Patricia MacCormack, Marietta Radomska, Nina Lykke, Ida Illerup Hansen, Philip R. Olson, Nicholas Manganas   +5 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Transgender and gender diverse individuals embodying endometriosis: a systematic review

Frontiers in Medicine
BackgroundTransgender and gender diverse (TGD) people embody social and health inequalities that disproportionately affect this community more than the cisgender population. Endometriosis is a chronic condition of the reproductive tract that affects 5–10%
Maddalena Giacomozzi, Maddalena Giacomozzi, Jip Bouwens, Jip Bouwens, Jip Bouwens, Stéphane Guy Aubin, Hester Pastoor, Petra Verdonk, Annemiek Nap   +8 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Insights from focus groups with trans and gender-diverse people with endometriosis: stories you tell, stories you don’t

Sexual and Reproductive Health Matters
Endometriosis is a chronic condition characterised by cyclic pain symptoms that often significantly affect health-related quality of life. Predominantly framed as a “woman's condition”, current research overlooks the experiences of transgender and gender-
Maddalena Giacomozzi, Jasmine Brazelton, Khushi Jeswani, Donna Ruumpol, Petra Verdonk, Annemiek Nap   +5 more
doaj   +1 more source

THE SILENCING OF QUEER VOICES IN THE LITIGATION OVER TRINITY WESTERN UNIVERSITY’S PROPOSED LAW SCHOOL

The Windsor Yearbook of Access to Justice, 2018
This article assesses to what extent the recent litigation over the accreditation of Trinity Western University’s proposed law school includes and considers queer voices.
Sarah Hamill, Pippa Feinstein
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Honoring Inágofli’e’ and Alofa: Developing a Culturally Grounded Health Promotion Model for Queer and Transgender Pacific Islanders

Genealogy
(1) Background: Although culturally grounded health interventions (CGHI) have shown efficacy in improving Indigenous health, few CGHI for Queer and Transgender Pacific Islander (QTPI) communities exist to address their health promotion.
Santino Giovanni Camacho, Wilson Ta, Kilohana Haitsuka, Såhi Velasco, Roldy Aguero Ablao, Falefia Jr. Brandon Fuamatu, Eve Cruz, V. Kalei Kanuha, Michael Spencer   +8 more
doaj   +1 more source

Queering Vulnerability: A Layered Bioethical Approach

Suomen Antropologi, 2019
Vulnerability is a concept often used in bioethics. However, it is seldom interrogated from a queer point of view. By queer inquiry, I refer to an umbrella understanding of gender and sexuality as diverse. In this article I discuss lesbian, gay, bisexual,
Tiia Sudenkaarne
doaj   +1 more source