Results 71 to 80 of about 1,191,294 (396)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Spectroscopic and thermodynamic characterization of the interaction of a new synthesized antitumor drug candidate 2H4MBBH with human serum albumin [PDF]

Pharmacia
In the present work we studied the interactions of a newly synthesized drug candidate, 2-(2-hydroxy-4-methoxybenzylidene)-1-(1H-benzimidazol-2-yl)hydrazine (2H4MBBH), with human serum albumin (HSA) by fluorescence spectroscopy.
Silviya Abarova, Katerina Stoitchkova, Svetlin Tzonev, Maria Argirova, Denitsa Yancheva, Neda Anastassova, Boris Tenchov   +6 more
doaj   +3 more sources

Lifetime quenching in Yb doped fibres

, 1997
We have discovered that in ytterbium-doped silica fibres the excited state lifetime of a fraction of the Yb ions can be quenched to a very small value, leading to a strong unbleachable loss.
Barber, P.R., Caplen, J.E., Hanna, D.C., Nilsson, J., Paschotta, R., Tropper, A.C.   +5 more
core   +1 more source

Properties of the mechanosensitive channel MscS pore revealed by tryptophan scanning mutagenesis [PDF]

, 2015
Funding This work was supported by a Wellcome Trust Programme grant [092552/A/10/Z awarded to I.R.B., S.M., J. H. Naismith (University of St Andrews, St Andrews, U.K.), and S. J. Conway (University of Oxford, Oxford, U.K.)] (T.R.
Akiko Rasmussen, Booth I. R., Booth I. R., Booth I. R., Harris D. C., Heloisa Galbiati, Ian R. Booth, Lakowicz J. R., Michelle D. Edwards, Samantha Miller, Shivani Singh, Tim Rasmussen, Weber G.   +12 more
core   +4 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Aggregation-Induced Emission (AIE)-Labeled Cellulose Nanocrystals for the Detection of Nitrophenolic Explosives in Aqueous Solutions

Nanomaterials, 2019
Aggregation-induced emission (AIE) active cellulose nanocrystals (TPE-CNCs) were synthesized by attaching tetraphenylethylene (TPE) to cellulose nanocrystals (CNCs).
Xiu Ye, Haoying Wang, Lisha Yu, Jinping Zhou   +3 more
doaj   +1 more source

Thioamide quenching of intrinsic protein fluorescence

Chemical Communications, 2012
Thioamides quench tryptophan and tyrosine fluorescence in a distance-dependent manner and thus can be used to monitor the binding of thioamide-containing peptides to proteins.
Jacob M, Goldberg, Rebecca F, Wissner, Alyssa M, Klein, E James, Petersson   +3 more
openaire   +3 more sources

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Fluorescent nanoparticles for sensing

, 2020
Nanoparticle-based fluorescent sensors have emerged as a competitive alternative to small molecule sensors, due to their excellent fluorescence-based sensing capabilities.
Acosta, Alarcón-Angeles, Albertazzi, Aldewachi, Ali, Ali, Alivisatos, Amelia, Amin, Arai, Arcudi, Bae, Bagwe, Behnke, Berti, Bhattacharyya, Biteen, Bruchez, Byrappa, Cai, Cao, Carregal-Romero, Chai, Chandra, Chen, Chen, Chen, Chen, Chen, Chen, Choi, Chu, Colom, De Luca, del Mercato, del Mercato, Derr, Dhenadhayalan, Diaz-Diestra, Ding, Dmitriev, Dong, Duong, Duong, Enkin, Fehérvári, Fernández-Argüelles, Fong, Fu, Furukawa, Gao, Govindaraju, Guo, Ha, Halter, Herschel, Hines, Hornig, Hou, Hu, Huang, Huang, Huang, Iyer, Jelinek, Jeong, Jiang, Jimenez de Aberasturi, Jin, Kim, Kircher, Kong, Lakowicz, Lan, Lee, Lemon, Leobandung, Leonhardt, Lepore, Li, Li, Li, Li, Li, Li, Li, Li, Li, Li, Lim, Lin, Lin, Liu, Liu, Liu, Liu, Liu, López-Duarte, Ma, Ma, Medintz, Melnychuk, Miao, Monteiro, Naccarato, Nandi, Ng, Nie, Nooney, Ou, Pan, Pellegrino, Peng, Pompa, Potter, Qian, Qian, Qu, Rakovich, Rao, Reisch, Riccò, Riedinger, Ruedas-Rama, Saha, Samokhvalov, See, Shamirian, Shang, Shang, Shangguan, Shao, Shen, SMITH, Song, Stich, Stryer, Stöber, Su, Sun, Tang, Thiyagarajan, Toh, Ukeda, Valeur, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wei, Wen, Widengren, Wolfbeis, Wu, Wu, Wu, Wu, Wu, Xie, Xie, Xu, Xu, Yang, Yang, Ye, Yin, Yin, Yu, Yu, Yu, Zadran, Zeng, Zhang, Zhang, Zhang, Zhao, Zheng, Zhu, Zor, Zorman   +183 more
core   +1 more source