Results 91 to 100 of about 624,160 (323)

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

Physical Representation-based Predicate Optimization for a Visual Analytics Database

open access: yes, 2019
Querying the content of images, video, and other non-textual data sources requires expensive content extraction methods. Modern extraction techniques are based on deep convolutional neural networks (CNNs) and can classify objects within images with ...
Anderson, Michael R.   +3 more
core   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Gene Annotation Easy Viewer (GAEV): Integrating KEGG’s Gene Function Annotations and Associated Molecular Pathways [version 3; peer review: 1 approved, 2 approved with reservations]

open access: yesF1000Research, 2019
We developed a Gene Annotation Easy Viewer (GAEV) that integrates the gene annotation data from the KEGG (Kyoto Encyclopedia of Genes and Genomes) Automatic Annotation Server.
Trung Huynh, Sen Xu
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Gene Annotation Easy Viewer (GAEV): Integrating KEGG’s Gene Function Annotations and Associated Molecular Pathways [version 2; referees: 1 approved, 2 approved with reservations]

open access: yesF1000Research, 2018
We developed a Gene Annotation Easy Viewer (GAEV) that integrates the gene annotation data from the KEGG (Kyoto Encyclopedia of Genes and Genomes) Automatic Annotation Server.
Trung Huynh, Sen Xu
doaj   +1 more source

A semantic relationship mining method among disorders, genes, and drugs from different biomedical datasets

open access: yesBMC Medical Informatics and Decision Making, 2020
Background Semantic web technology has been applied widely in the biomedical informatics field. Large numbers of biomedical datasets are available online in the resource description framework (RDF) format.
Li Zhang   +5 more
doaj   +1 more source

Online Sorting via Searching and Selection

open access: yes, 2009
In this paper, we present a framework based on a simple data structure and parameterized algorithms for the problems of finding items in an unsorted list of linearly ordered items based on their rank (selection) or value (search).
Gupta, Ankur   +2 more
core   +1 more source

User Feedback in Probabilistic XML [PDF]

open access: yes, 2007
Data integration is a challenging problem in many application areas. Approaches mostly attempt to resolve semantic uncertainty and conflicts between information sources as part of the data integration process.
Keijzer, A. de, Keulen, M. van
core   +1 more source

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