Results 91 to 100 of about 635,069 (331)

KRAS and GNAS mutations in cell‐free DNA and in circulating epithelial cells in patients with intraductal papillary mucinous neoplasms—an observational pilot study

open access: yesMolecular Oncology, EarlyView.
This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke   +12 more
wiley   +1 more source

Region-Based Shape Matching for Automatic Image Annotation and Query-by-Example

open access: yesJournal of Visual Communication and Image Representation, 1997
We present a method for automatic image annotation and retrieval based on query-by-example by region-based shape matching. The proposed method consists of two parts: region selection and shape matching.
E. Saber, A. Tekalp
semanticscholar   +1 more source

Compiling Away Set Containment and Intersection Joins [PDF]

open access: yes, 2002
We investigate the effect of query rewriting on joins involving set-valued attributes in object-relational database management systems. We show that by unnesting set-valued attributes (that are stored in an internal nested representation) prior to the ...
Helmer, Sven, Moerkotte, Guido
core  

Adaptive Hierarchical Clustering Using Ordinal Queries

open access: yes, 2018
In many applications of clustering (for example, ontologies or clusterings of animal or plant species), hierarchical clusterings are more descriptive than a flat clustering.
Emamjomeh-Zadeh, Ehsan, Kempe, David
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Image Retrieval Based on Learning to Rank and Multiple Loss

open access: yesISPRS International Journal of Geo-Information, 2019
Image retrieval applying deep convolutional features has achieved the most advanced performance in most standard benchmark tests. In image retrieval, deep metric learning (DML) plays a key role and aims to capture semantic similarity information carried ...
Lili Fan   +4 more
doaj   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Adapting to the Shifting Intent of Search Queries [PDF]

open access: yes, 2009
Search engines today present results that are often oblivious to abrupt shifts in intent. For example, the query `independence day' usually refers to a US holiday, but the intent of this query abruptly changed during the release of a major film by that ...
Mishra, Nina   +2 more
core   +2 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

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