Results 91 to 100 of about 650,464 (329)

Validating specifications of dynamic systems using automated reasoning techniques [PDF]

open access: yes, 1995
In this paper, we propose a new approach to validating formal specifications of observable behavior of discrete dynamic systems. By observable behavior we mean system behavior as observed by users or other systems in the environment of the system ...
Feenstra, Remco, Wieringa, Roel
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

A semantic relationship mining method among disorders, genes, and drugs from different biomedical datasets

open access: yesBMC Medical Informatics and Decision Making, 2020
Background Semantic web technology has been applied widely in the biomedical informatics field. Large numbers of biomedical datasets are available online in the resource description framework (RDF) format.
Li Zhang   +5 more
doaj   +1 more source

Shape similarity matching for query-by-example

open access: yesPattern Recognition, 1998
This paper describes a unified approach for two-dimensional (2-D) shape matching and similarity ranking of objects by means of a modal representation. In particular, we propose a new shape-similarity metric in the eigenshape space for object/image retrieval from a visual database via query-by-example.
Bilge Günsel, A. Murat Tekalp
openaire   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

User Feedback in Probabilistic XML [PDF]

open access: yes, 2007
Data integration is a challenging problem in many application areas. Approaches mostly attempt to resolve semantic uncertainty and conflicts between information sources as part of the data integration process.
Keijzer, A. de, Keulen, M. van
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Cooperative answering of queries based on hierarchical decision attributes

open access: yesComputer Assisted Methods in Engineering and Science, 2022
This paper considers decision systems (see [6]) with decision attributes which are hierarchical. Atomic queries are built only from values of decision attributes.
Zbigniew W. Raś, Xin Zhang
doaj  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

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