Results 61 to 70 of about 613,746 (324)
Introducing new constructs for data modelling and column generation in LP modelling languages [PDF]
, 1993 Through popular implementation of structured query language (SQL) and query-by-example(QBE) relational databases have become the de-facto industry standard for data modelling.We consider the indices, sets, and the declarative form of Linear Programming ...
Kristjansson, B +3 more
core
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Active classification with comparison queries
, 2017 We study an extension of active learning in which the learning algorithm may ask the annotator to compare the distances of two examples from the boundary of their label-class. For example, in a recommendation system application (say for restaurants), the
Kane, Daniel M. +3 more
core +1 more source
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
Adaptive Hierarchical Clustering Using Ordinal Queries
, 2018 In many applications of clustering (for example, ontologies or clusterings of animal or plant species), hierarchical clusterings are more descriptive than a flat clustering.
Emamjomeh-Zadeh, Ehsan, Kempe, David
core +1 more source
Provably-secure symmetric private information retrieval with quantum cryptography
, 2020 Private information retrieval (PIR) is a database query protocol that provides user privacy, in that the user can learn a particular entry of the database of his interest but his query would be hidden from the data centre.
Kon, Wen Yu, Lim, Charles Ci Wen
core +1 more source
TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation
FEBS Letters, EarlyView.TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling +4 more
wiley +1 more source
LeadOp+R: Structure-Based Lead Optimization With Synthetic Accessibility
Frontiers in Pharmacology, 2018 We previously described a structure-based fragment hopping for lead optimization using a pre-docked fragment database, “LeadOp,” that conceptually replaced “bad” fragments of a ligand with “good” fragments while leaving the core of the ligand intact thus
Fang-Yu Lin +3 more
doaj +1 more source
Two Classical Queries versus One Quantum Query [PDF]
, 1998 In this note we study the power of so called query-limited computers. We compare the strength of a classical computer that is allowed to ask two questions to an NP-oracle with the strength of a quantum computer that is allowed only one such query.
van Dam, Wim
core +2 more sources
FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source