Results 221 to 230 of about 3,779,106 (381)

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

Improved Arabic query expansion using word embedding. [PDF]

Sci Rep
Al-Lahham YA, Almatarneh S, Alshammari K, Al-Smadi M.   +3 more
europepmc   +1 more source

Foundation Model‐Enabled Multimodal Deep Learning for Prognostic Prediction in Colorectal Cancer with Incomplete Modalities: A Multi‐Institutional Retrospective Study

Advanced Science, EarlyView.
FLARE, a multimodal AI framework, combines pathology slides, radiology scans, and clinical reports to predict colorectal cancer outcomes, even when some tests are missing. Evaluated retrospectively in 1679 patients from four medical centers, it consistently achieved the best prognostic accuracy and clearly separated high‐ and low‐risk groups.
Linhao Qu, Chengsheng Zhang, Yingyong Hou, Feng Tang, Weiqi Sheng, Dan Huang, Zhijian Song   +6 more
wiley   +1 more source

Transforming wearable data into personal health insights using large language model agents. [PDF]

Nat Commun
Merrill MA, Paruchuri A, Rezaei N, Kovacs G, Perez J, Liu Y, Schenck E, Hammerquist N, Sunshine J, Tailor S, Ayush K, Su HW, He Q, McLean CY, Malhotra M, Patel S, Zhan J, Althoff T, McDuff D, Liu X.   +19 more
europepmc   +1 more source

Subvoxel Control of Fiber Orientation via Multidirectional Shearing in 3D Printing

Advanced Science, EarlyView.
A novel 3D printing technique enables subvoxel control of fiber orientation in all three directions through multidirectional shearing using nozzle rotation and inclination. It allows localized and tunable mechanical and thermal responses through programmable microstructures within a strand.
Berin Šeta, Marco Brander, Michael Sandberg, Md. Tusher Mollah, Vipin Kumar, Jon Spangenberg   +5 more
wiley   +1 more source

A multi module a.i. system for intelligent health insurance support using retrieval augmented generation. [PDF]

Sci Rep
Hanmante S, Patil S, Shahade AK.
europepmc   +1 more source

Using Genome Query Language to uncover genetic variation. [PDF]

Bioinformatics, 2014
Kozanitis C, Heiberg A, Varghese G, Bafna V.   +3 more
europepmc   +1 more source

Logical Foundations and Complexity of 4QL, a Query Language with Unrestricted Negation

, 2010
Jan Małuszyński, Andrzej Szałas
openalex   +2 more sources

SVQL: A SQL Extended Query Language for Video Databases

, 2015
Chenglang Lu, Mingyong Liu, Zongda Wu
semanticscholar   +1 more source

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source