Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore +20 more
wiley +1 more source
Medical QA dialogue datasets in RAG systems performance evaluation and ChatGPT optimization. [PDF]
Muhetaer M +4 more
europepmc +1 more source
Language-integrated privacy-aware distributed queries
Guido Salvaneschi +5 more
openalex +2 more sources
Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development
Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu +8 more
wiley +1 more source
Performance of Large Language Models in Lung Cancer Clinical Decision-Making: A Comparative Analysis Based on DeepSeek, Grok, and GPT. [PDF]
Zhang Y, Yang D, Shi Y, Liu Y.
europepmc +1 more source
On describing human white matter anatomy: the white matter query language. [PDF]
Wassermann D +6 more
europepmc +1 more source
Determination of the Exchange Current Density at Lithium │ Polymer Electrolyte Interfaces
This work presents a comprehensively validated method to determine the exchange current density (j0) at the interface of lithium metal and polymer electrolytes by combining electrochemical impedance spectroscopy with Bayesian inference and distribution of relaxation times analyses to successfully deconvolute solid electrolyte interphase and charge ...
Katrin Geng +4 more
wiley +1 more source
GDC Cohort Copilot: an AI copilot for curating cohorts from the genomic data commons. [PDF]
Song S +4 more
europepmc +1 more source
AI‐Directed 3D Printing of Hierarchical Polyurethane Foams
Digitally guided direct ink writing, combined with AI‐generated design, enables the fabrication of hierarchical polyurethane foams with tunable multiscale porosity. This approach produces architected foams featuring interconnected open‐cell networks and tailored mechanical properties, advancing the development of adaptive, high‐performance materials ...
Dhanush Patil +15 more
wiley +1 more source
A large language model for deriving spectral embeddings for accurate compound identification in mass spectrometry. [PDF]
Xu Y, Ma Y, Xu W, Yang Z, Ting KM.
europepmc +1 more source

