Results 171 to 180 of about 2,685,258 (302)

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Acceptability of screening for celiac disease at Youth Health Care Centers in The Netherlands. [PDF]

Eur J Pediatr
de Vries W, van Geloven N, Mearin ML, Smit L, de Vries MC, Meijer-Boekel CR.   +5 more
europepmc   +1 more source

Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain‐Machine Interface

Advanced Science, EarlyView.
Episodic memory weaves together what, where, and when of experience into a personal narrative. Cutting‐edge AI models may decode this intricate process in real‐life settings, revealing how neural activity encodes naturalistic memories. By merging AI with brain–machine interfaces, researchers are edging closer to mapping and even engineering memory ...
Dong Song
wiley   +1 more source

Latent trait or sum score: addressing measurement challenges in the prediction of self-rated symptom outcomes in psychological treatment. [PDF]

Front Psychol
Hentati Isacsson N, Johansson M, Kaldo V.   +2 more
europepmc   +1 more source

The Emerging Parkinson's Disease Oxylipin‐Ome

Advanced Science, EarlyView.
ABSTRACT Parkinson Disease (PD) is increasingly considered a proteinopathy and lipidopathy. This proteinopathy+lipidopathy paradigm has been further refined to a fatty acid (FA)‐opathy, centering dysregulated FA metabolism as fundamental in PD lipid dysfunction.
Julia C. Kelliher, Saranna Fanning
wiley   +1 more source

Pediatric Intensive Care Core Outcomes-a modified Delphi consensus process (PIC-CO). [PDF]

Crit Care
Mand N, Lieftüchter V, Westhoff JH, Hort S, Biedermann R, Müller-Brandes C, Merker M, Fuchs H, Cardona F, Beer A, Hoffmann F, Regner F, Lampe S, Pönicke C, Härtel C, Brickmann C, Bruns N, Section of Pediatric Intensive Care and Emergency Medicine of the German Interdisciplinary Association of Intensive Care and Emergency Medicine (DIVI).   +17 more
europepmc   +1 more source

Endometrial Epithelial Lactate Deficiency Drives CD8+ T‐Cells Dysregulation in Unexplained Recurrent Implantation Failure

Advanced Science, EarlyView.
Unexplained recurrent implantation failure (RIF) represents a significant clinical challenge. Our results demonstrate that reduced lactate production in the RIF endometrium impairs the suppression of cytotoxic CD8+ T‑cells, allowing their proliferation and thereby disrupting the local immune balance essential for successful embryo implantation.
Yuanlin He, Kang Ke, Qingxia Meng, Yichun Guan, Jichun Tan, Hong Lv, Boxian Huang, Chan Tian, Qinyan Zou, Mingxing An, Yao Gao, Jingjing Chen, Xiaoyu Wei, Xi Wang, Hongxia Ma, Yuan Lin, Feiyang Diao, Yayun Gu, Zhibin Hu   +18 more
wiley   +1 more source

Validity, reliability, and comparison of the Indonesian version of two baumann skin type indicator (BSTI) questionnaires. [PDF]

PLoS One
Batubara IS, Sitohang IBS, Widaty S, Nilasari H, Kekalih A, Chairunnisa S.   +5 more
europepmc   +1 more source

Stable Diffusion Models Reveal a Persisting Human–AI Gap in Visual Creativity

Advanced Science, EarlyView.
This study examines visual creativity in humans and generative AI using the TCIA framework. Human artists outperform AI overall, yet structured human guidance substantially improves AI outputs and evaluations. Findings reveal that alignment with human creativity depends critically on contextual framing, highlighting both the promise and current ...
Silvia Rondini, Claudia Alvarez‐Martin, Paula Angermair‐Barkai, Olivier Penacchio, Marc Paz, Matthew Pelowski, Dan Dediu, Antoni Rodriguez‐Fornells, Xim Cerda‐Company   +8 more
wiley   +1 more source

Validation of the Wood Mental Fatigue Inventory in adolescents with myalgic encephalomyelitis/chronic fatigue syndrome. [PDF]

Brain Behav Immun Health
Welch DC, Edwards CC, Broussard CA, Swope ME, Christoforou ME, Matson PA, Azola AM, Rowe PC.   +7 more
europepmc   +1 more source