Results 101 to 110 of about 196,937 (287)

IL1R2 Marks and Sorts a Spermatogonial Stem Cell Population Critical for Restoring Spermatogenesis Upon Interruption in Mammals

open access: yesAdvanced Science, EarlyView.
Spermatogonial stem cells (SSCs) provide critical support to spermatogenesis. Here, the author established Il1r2 as a sorting marker for SSCs, with which further insights into the SSC heterogeneity and dynamic features can be obtained. They also confirmed findings in both mouse and human, thus validating IL1R2 as the surface marker for isolating and ...
Pengyu Li   +19 more
wiley   +1 more source

Nitric oxide donor S‐Nitroso‐N‐acetyl penicillamine for hepatic stellate cells to restore quiescence

open access: yesPediatric Discovery
Liver fibrosis is a hepatic scar repair response associated with a wide range of liver injuries, which is mediated by an imbalance between extracellular matrix (ECM) synthesis and degradation, leading to massive ECM deposition and disruption of normal ...
Junbao Du   +5 more
doaj   +1 more source

The 2-D magnetohydrostatic configurations leading to flares or quiescent filament eruptions [PDF]

open access: yes
To investigate the cause of flares and quiescent filament eruptions the quasi-static evolution of a magnetohydrostatic (MHS) model was studied. The results lead to a proposal that: the sudden disruption of an active-region filament field configuration ...
An, C.-H., Moore, R. L., Suess, S. T.
core   +1 more source

Structural and Functional Characterization of EXPO‐Derived Extracellular Vesicles in Plants

open access: yesAdvanced Science, EarlyView.
In this study, 3D electron tomography (ET), cryo‐ET, and immunogold transmission electron microscopy (TEM) are employed to characterize plant extracellular vesicles (EVs) under physiological conditions. EVs are classified into three distinct categories according to their size, content, and molecular‐marker profiles. Furthermore, Exo70E2‐positive medium
Jiayang Gao   +12 more
wiley   +1 more source

Initiation and Early Kinematic Evolution of Solar Eruptions

open access: yes, 2020
We investigate the initiation and early evolution of 12 solar eruptions, including six active region hot channel and six quiescent filament eruptions, which were well observed by the \textsl{Solar Dynamics Observatory}, as well as by the \textsl{Solar ...
Cheng, X.   +7 more
core   +1 more source

Data‐Driven Printability Modeling of Hydrogels for Precise Direct Ink Writing Based on Rheological Properties

open access: yesAdvanced Science, EarlyView.
A predictive model for 3D printability is developed by integrating rheological analysis, including the Large Amplitude Oscillatory Shear (LAOS) test, with machine learning. With prediction errors under 10%, the model shows that post‐extrusion recovery controls horizontal printability, while high‐strain‐rate nozzle flow dictates vertical printability ...
Eun Hui Jeong   +7 more
wiley   +1 more source

A Patient‐Derived Organ‐on‐Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...
Darbaz Adnan   +11 more
wiley   +1 more source

A Complex Interplay between Wnt/β-Catenin Signalling and the Cell Cycle in the Adult Liver

open access: yesInternational Journal of Hepatology, 2012
Canonical Wnt signalling, governed by its effector β-catenin, is known for a long time as playing an important role in development, tissue homeostasis, and cancer. In the liver, it was unravelled as both an oncogenic pathway involved in a subset of liver
Angélique Gougelet, Sabine Colnot
doaj   +1 more source

The Dynamical Consequences of Spontaneous Current Sheets in Quiescent Prominences

open access: yesThe Astrophysical Journal Supplement Series, 2005
The solar corona is continually being injected with magnetic flux from the solar interior, flux that cannot be annihilated in bulk by the electrically highly conducting corona. Observations have shown that mass loss through downflows within solar prominences may be responsible for the ascent and eventual eruption of these prominences.
G. J. D. Petrie, B. C. Low
openaire   +1 more source

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

open access: yesAdvanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen   +8 more
wiley   +1 more source

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