Results 111 to 120 of about 196,937 (287)

Delayed rectifier K currents in NF1 Schwann cells

open access: yesNeurobiology of Disease, 2003
K+ (K) currents are related to the proliferation of many cell types and have a relationship to second messenger pathways implicated in regulation of the cell cycle in development and certain disease states.
Lynne A Fieber   +3 more
doaj   +1 more source

CLEAR I: Ages and Metallicities of Quiescent Galaxies at $\mathbf{1.0 < z < 1.8}$ Derived from Deep Hubble Space Telescope Grism Data

open access: yes, 2018
We use deep \textit{Hubble Space Telescope} spectroscopy to constrain the metallicities and (\editone{light-weighted}) ages of massive ($\log M_\ast/M_\odot\gtrsim10$) galaxies selected to have quiescent stellar populations at $1 ...
Brammer, Gabriel   +16 more
core   +1 more source

Electrical Control of the Transduction Channels’ Gating Force in Mechanosensory Hair Cells

open access: yesAdvanced Science, EarlyView.
The inner ear's hair cells rely on mechanosensitive ion channels to convert vibrations of their hair‐bundle into electrical signals. We show that varying the electrical potential (U) across the sensory epithelium modulates a key determinant of mechanosensitivity—the gating force (FG)—by modulating the gating swing (d), ranging from the size of the ...
Achille Joliot   +2 more
wiley   +1 more source

Pressurization of cryogens: A review of current technology and its applicability to low-gravity conditions [PDF]

open access: yes
A review of technology, history, and current status for pressurized expulsion of cryogenic tankage is presented. Use of tank pressurization to expel cryogenic fluids will continue to be studied for future spacecraft applications over a range of operating
Vandresar, N. T.
core   +1 more source

Western Diet Inhibits FUT7‐Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease

open access: yesAdvanced Science, EarlyView.
In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...
Qian Zhou   +13 more
wiley   +1 more source

Gm-Realization of Controlled-Gain Current Follower Transconductance Amplifier

open access: yesThe Scientific World Journal, 2013
This paper describes the conception of the current follower transconductance amplifier (CFTA) with electronically and linearly current tunable. The newly modified element is realized based on the use of transconductance cells (Gms) as core circuits.
Worapong Tangsrirat
doaj   +1 more source

In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus. [PDF]

open access: yes, 2015
Viruses in the Reoviridae, like the triple-shelled human rotavirus and the single-shelled insect cytoplasmic polyhedrosis virus (CPV), all package a genome of segmented double-stranded RNAs (dsRNAs) inside the viral capsid and carry out endogenous ...
Chang, Winston   +5 more
core  

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

open access: yesAdvanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi   +18 more
wiley   +1 more source

Targeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2⁺ Macrophage‐Derived Fn1 via FAK/RhoA/ROCK Signaling

open access: yesAdvanced Science, EarlyView.
Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang   +9 more
wiley   +1 more source

Feeding the Dead: Neutral Gas Inflow in a Long-quenched Ancient Massive Galaxy at z ∼ 2.7 Observed with JWST/NIRSpec

open access: yesThe Astrophysical Journal
We report the spectroscopic detection of neutral gas inflow into a massive ( M _*  ≃ 4 × 10 ^10 M _⊙ ) quiescent galaxy observed at z _spec  = 2.6576 with the James Webb Space Telescope (JWST).
Davide Bevacqua   +18 more
doaj   +1 more source

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