Results 121 to 130 of about 196,937 (287)

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

A Massive Quiescent Galaxy in a Group Environment at z = 4.53

The Astrophysical Journal
We report on the spectroscopic confirmation of a massive quiescent galaxy at z _spec = 4.53 in the COSMOS field. The object was first identified as a galaxy with suppressed star formation at z _phot ∼ 4.65 from the COSMOS2020 catalog.
Takumi Kakimoto, Masayuki Tanaka, Masato Onodera, Rhythm Shimakawa, Po-Feng Wu, Katriona M. L. Gould, Kei Ito, Shuowen Jin, Mariko Kubo, Tomoko L. Suzuki, Sune Toft, Francesco Valentino, Kiyoto Yabe   +12 more
doaj   +1 more source

A 95.43%-Peak-Efficiency Buck Converter With Seamless PWM/PFM Transition and 12.3-μA Quiescent Current for Wide-Load Applications

IEEE Access
This study presents a high-efficiency synchronous buck converter IC featuring wide load-range capability and ultra-low power consumption. The design employs an integrated PWM/PFM control scheme where a clamp circuit integrated into the PWM control loop ...
Xiao-Hui Hu, Wan-Yuan Qu, Yong Ding
doaj   +1 more source

On the Origin of [OII] Emission in Red Sequence and Post-starburst Galaxies

, 2005
We investigate the emission-line properties of galaxies with red rest-frame colors using spectra from SDSS DR4. Emission lines are detected in more than half of the red galaxies.
Binette L., David Koo, Goto T., Goudfrooij P., Heckman T. M., Jeffrey A. Newman, Marc Davis, Nicholas Konidaris, Renbin Yan, Rola C. S., S. M. Faber, Sarzi M.   +11 more
core   +1 more source

The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP‐1 Signaling in Colorectal Cancer

Advanced Science, EarlyView.
In wild‐type intestinal epithelial cells, KDM6B demethylates SLC10A2 to promote its expression, after which SLC10A2 suppresses ERK phosphorylation, inhibiting AP‐1 (Fos/Jun) transcription and chemokine production. In KDM6B‐deficient intestinal epithelial cells, SLC10A2 methylation increases, and its expression decreases.
Zhibo Hu, Jing Xun, Bin Liu, Xiaolin Jiang, Yingdi Han, Huichao Yang, Qi Gao, Ruifang Gao, Aimin Zhang, Xueliang Wu, Dapeng Zhang, Dihua Li, Tian Li, Shimin Yang, Ximo Wang, Xiangyang Yu, Qi Zhang   +16 more
wiley   +1 more source

Autocrine Netrin‐1 Signaling in Hepatic Stellate Cells Drives Liver Fibrosis and Diet‐Induced Metabolic Dysfunction‐Associated Steatohepatitis in Mice

Advanced Science, EarlyView.
Netrin‐1 expression is upregulated in hepatic stellate cells (HSCs) during metabolic dysfunction–associated steatohepatitis and injury‐mediated liver fibrosis. Secreted Netrin‐1 establishes an autocrine positive feedback loop by binding to UNC5B receptors on HSCs.
Jiahui Zhao, Yajie Peng, Hongyan Lei, Tianyi Wang, Huajuan Wang, Bo Wang, Jin Li, Xiaoying Li, Xuelian Xiong   +8 more
wiley   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Compact Quiescent Galaxies at Intermediate Redshifts

, 2014
From several searches of the area common to the Sloan Digital Sky Survey and the United Kingdom Infrared Telescope Infrared Deep Sky Survey, we have selected 22 luminous galaxies between $z \sim$ 0.4 and $z \sim$ 0.9 that have colors and sizes similar to
Hsu, Li-Yen, Shih, Hsin-Yi, Stockton, Alan   +2 more
core   +1 more source

Bioinspired Tissue Transparency: Achieving Sclera‐to‐Cornea Transplantation

Advanced Science, EarlyView.
A bioinspired decellularization‐compression‐locking tactic (DCLT) is developed to transform human sclerae into transparent corneal substitutes. These clear, robust, and pro‐regenerative substitutes are capable of repairing complex corneal injuries, including chemical burns, keratoconus, and penetrating wounds, demonstrating their clinical potential to ...
Xiuli Sun, Long Zhao, Zhen Shi, Jingting Wang, Shang Yang, Xia Qi, Hengrui Zhang, Ting Wang, Weiyun Shi   +8 more
wiley   +1 more source