Results 161 to 170 of about 196,937 (287)

The myth of the metabolic baseline: sleep–wake cycles undermine a foundational assumption in organismal biology

Biological Reviews, EarlyView.
ABSTRACT Basal and standard metabolic rate (BMR and SMR) are cornerstones of physiological ecology and are assumed to be relatively fixed intrinsic properties of organisms that represent the minimum energy required to sustain life. However, this assumption is conceptually flawed. Many core maintenance processes underlying SMR are temporally partitioned
Helena Norman, Daphne Cortese, Amelia Munson, Jan Lindström, Shaun S. Killen   +4 more
wiley   +1 more source

Analysis of experimental colorectal liver metastases identifies distinct proliferation-independent transcriptional programs in micro- versus macrometastases. [PDF]

J Transl Med
Peters NA, Heinz MC, Küçükköse E, Viergever BJ, Baars M, Amini M, Huismans MA, Andel D, Verheem A, Vercoulen Y, Snippert H, Borel Rinkes IHM, Kranenburg O.   +12 more
europepmc   +1 more source

Geological processes shaping freshwater biodiversity: a synthesis of global evidence

Biological Reviews, EarlyView.
ABSTRACT Recent genomic data highlight the key roles of geological processes in shaping the diversification and biogeography of freshwater lineages. Specifically, physical processes such as tectonic uplift, erosion, glaciation, lake formation, and sea‐level fluctuation contribute extensively to the evolution of biotic diversity within and among ...
Jonathan M. Waters, Christopher P. Burridge, David Craw, James S. Albert   +3 more
wiley   +1 more source

Fungal-Bacterial Dysbiosis in IBD: Microbial Biomarkers of Disease Activity. [PDF]

Microbiologyopen
Arribas-Rodríguez E, García-Pizarro M, De Prado Á, Santiago-Carretero M, Hernández M, Jiménez BV, García-Alonso J, Barrio J, Eiros JM, Arranz E, Bernardo D, Fernández-Salazar L, Cuesta-Sancho S.   +12 more
europepmc   +1 more source

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, EarlyView.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

Design of a Bandgap Reference Circuit for MEMS Integrated Accelerometers. [PDF]

Micromachines (Basel)
Zhang W, Wang S, Wang Y, Fu Q, Wang P, Li X.   +5 more
europepmc   +1 more source

Dynamics of natural killer cell function upon recurrent stimulation

Biotechnology Progress, EarlyView.
Weekly stimulation of peripheral blood‐derived NK cells with engineered K562 feeder cells resulted in two distinct growth phases, shifting around Day 21–26. Cells in growth phase 2 exhibited slower growth, reduced metabolic activity, and lower cytotoxicity than cells from growth phase 1, which has implications for NK cell biomanufacturing.
Jennifer One, Janani Narayan, Frank Cichocki, Wei‐Shou Hu, Samira M. Azarin   +4 more
wiley   +1 more source

Nanogel‐Mediated Immunotherapy to Tackle Cancer and Inflammatory Diseases

ChemistryEurope, EarlyView.
Nanogels formed through self‐assembly, microemulsion, or precipitation polymerization method enable precise delivery of immunotherapeutic factors and immune cell targeting, thus effectively modulating immune responses. This review highlights recent advances in stimuli‐responsive nanogel design, underlying mechanisms, and their potentials to tackle ...
Ziwen Zhang, Jinxia Wang, Guang‐Zhi Jin, István Bányai, Dzmitry Shcharbin, Ivan Stoikov, Mingwu Shen, Xiangyang Shi   +7 more
wiley   +1 more source

<p>Beyond hepatic stellate cell heterogeneity: Resolving fibrosis, restoring regeneration (Review)</p>. [PDF]

Int J Mol Med
Gao C, Chen G, Jia H, Zhu H, Cai Y, Yang D, Zhao K.   +6 more
europepmc   +1 more source

Slip versus dilation tendency parameter space as a tool for prospecting structurally controlled geothermal systems in greenfield: insights from the greater Ruhr region

Deep Underground Science and Engineering, EarlyView.
This study highlights that with the static and time‐dependent evolution of slip versus dilation tendency parameter space, structurally controlled deep geothermal systems can be selected within areas of higher permeability and lower seismic hazard. Abstract Faults play a vital role in the Earth's hydraulic system by facilitating fluid flow when dilating
Michal Kruszewski, Alessandro Verdecchia, Oliver Heidbach, Rebecca M. Harrington, David Healy   +4 more
wiley   +1 more source