Results 191 to 200 of about 196,937 (287)

Single-cell RNA sequencing reveals a quiescence-senescence continuum and distinct senotypes following chemotherapy. [PDF]

Nat Commun
Fernandez B, Passanisi VJ, Ashraf HM, Spencer SL.   +3 more
europepmc   +1 more source

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

Old Scars, New Bleeds: Revisiting Coagulopathy in Quiescent Crohn's Disease. [PDF]

Eur J Case Rep Intern Med
Patel S, Khattak R, Patel R, Kumar SA, Kulkarni AR.   +4 more
europepmc   +1 more source

Motion Mitigation Techniques for Abdominal and Cardiac MR Imaging

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT MRI of the heart and abdominal organs provides unparalleled soft tissue contrast and quantitative biomarkers, yet remains highly susceptible to physiological motion. Contractions of the myocardium, respiratory excursions, peristalsis, vascular pulsatility, and unpredictable bulk patient movement generate artifacts that impair image quality ...
Eric M. Schrauben, Gastao Lima da Cruz, Christopher W. Roy, Thomas Küstner   +3 more
wiley   +1 more source

Prophylactic heminephrectomy for an asymptomatic, non-functioning moiety in pediatric duplex systems: is cancer prevention justified? [PDF]

Front Pediatr
Zhanghuang C, Long N, Yan B.
europepmc   +1 more source

Epigenetic inflammatory memory and periodontal disease: Mechanisms and clinical significance for comorbidities

Journal of Periodontology, EarlyView.
Abstract Historically, immunological memory was considered an exclusive feature of adaptive immunity. However, innate immune cells have recently been shown to record and maintain epigenetically imprinted memory of earlier infectious or inflammatory challenges.
George Hajishengallis
wiley   +1 more source

Transsulfuration metabolism is essential for ferroptosis resistance in quiescent endothelial cells. [PDF]

Cell Death Dis
Oberkersch RE, Lidonnici J, Andreuzza S, Zambon E, Imperato G, Pedretti S, Mitro N, Santoro MM.   +7 more
europepmc   +1 more source

Clinical, manometric, genetic, and histologic associations in pediatric intestinal pseudo‐obstruction: A case series

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Pediatric intestinal pseudo‐obstruction (PIPO) is a severe bowel motility disorder characterized by impaired propulsion of gastrointestinal contents without mechanical obstruction. PIPO encompasses congenital and acquired disorders, including neuropathies, myopathies, and mesenchymopathies.
Sharon Wolfson, Myra Butrviengpunt, Naomi Tjaden, Alain J. Benitez, Archana S. Kota, Jennifer Webster, Prasanna Kapavarapu, Hayat Mousa, Robert O. Heuckeroth   +8 more
wiley   +1 more source

An in vitro tumor recurrence model based on platinum-resistant colon cancer cells as a research tool for studying cancer cell dormancy. [PDF]

PLoS One
Morshneva A, Gnedina O, Igotti M.
europepmc   +1 more source

Symptom cluster profiles in adolescents with inflammatory bowel disease: Cross‐sectional study using ImproveCareNow data

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Sleep disturbance, pain, anxiety, depression, and fatigue are prevalent in adolescents and young adults with inflammatory bowel disease (IBD). These symptoms often present in co‐occurring sets, known as symptom clusters. We aimed to identify distinct symptom clusters and factors associated with symptom profiles in adolescents with ...
Caeli Malloy, Kurt Kroenke, Patrick O. Monahan, Susan M. Rawl, Steven J. Steiner, Wendy R. Trueblood Miller, for the ImproveCareNow Pediatric IBD Learning Health System   +6 more
wiley   +1 more source