Results 221 to 230 of about 31,201 (252)
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Archives of Internal Medicine, 1985
Four patients developed nonthrombocytopenic purpura two to three weeks after initiation of quinidine therapy. The skin lesions disappeared and did not recur after cessation of quinidine therapy. Histologic examination revealed leukocytoclastic vasculitis with deposition of C3, IgA, and/or IgM in the small dermal vessels.
Meir Shalit +6 more
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Four patients developed nonthrombocytopenic purpura two to three weeks after initiation of quinidine therapy. The skin lesions disappeared and did not recur after cessation of quinidine therapy. Histologic examination revealed leukocytoclastic vasculitis with deposition of C3, IgA, and/or IgM in the small dermal vessels.
Meir Shalit +6 more
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Disposition of Quinidine in the Rabbit
Journal of Pharmaceutical Sciences, 1982Quinidine shows two-compartment characteristics in rabbits with a terminal half-life of 67 min for total drug and 58 min for unbound drug. Statistically, the values are not significantly different from each other (p greater than 0.05). The clearances for total and unbound drug are 52 and 464 ml/min/kg, respectively, and the total and unbound apparent ...
Jin‐Ding Huang +2 more
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Quinidine Fever: An Unusual Manifestation of Quinidine Allergy
Chest, 1973A patient with mitral stenosis was placed on quinidine for control of atrial fibrillation. Eight days later she developed high fever, chills, and diarrhea. Antibiotic therapy was given, and quinidine was discontinued, with abatement of the fever. Readministration of quinidine resulted in a prompt rise in temperature and confirmed the diagnosis of ...
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Quinidine-Rifampin Interaction
New England Journal of Medicine, 1981DRUG interactions with quinidine are likely to be clinically important, since quinidine is used in the treatment and prophylaxis of potentially serious arrhythmias, and since there is a relatively narrow range between the therapeutic and toxic concentrations.1 An interaction between quinidine and the anticonvulsant drugs primidone and phenobarbital has
Twum-Barima Y, Carruthers Sg
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NMR Quantitative Analysis of Quinidine in Mixtures of Quinidine and Hydroquinidine
Journal of Pharmaceutical Sciences, 1973A new procedure for the rapid quantitative analysis of quinidine in mixtures of quinidine and hydroquinidine is described. The method is based upon measurement of the NMR spectrum of these compounds in deuterated chloroform, using 2,3,5-tri-bromothiophene as an internal standard. The signal chosen is from the vinyl group of quinidine.
Tho Huynh-Ngoc, Gerard Sirois
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Archives of Internal Medicine, 1986
To the Editor. —The article on quinidine-induced hepatitis by Knobler et al 1 is interesting and important. Curiously, no mention is made of the reason why quinidine was given to 1500 patients in a ten-year period at their hospital. Hopefully, the recovery that occurred after cessation of the drug will not encourage its use. Indeed, although quinidine
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To the Editor. —The article on quinidine-induced hepatitis by Knobler et al 1 is interesting and important. Curiously, no mention is made of the reason why quinidine was given to 1500 patients in a ten-year period at their hospital. Hopefully, the recovery that occurred after cessation of the drug will not encourage its use. Indeed, although quinidine
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A Quinidine Transformation Product Isolated from Quinidine Injection
Journal of Pharmaceutical Sciences, 1969A substance found in quinidine gluconate injection containing α-thioglycerol as a stabilizer has been identified as α-(6 – methoxy – 4 – quinolyl) – 5 – (5,6 – dihydroxy – 3 – thia – n -hexyl)-2-quinuclidine methanol. It is a product of anti-Markowni-koff addition of thioglycerol to the vinyl group of quinidine.
Millard Maienthal, Joseph Levine
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