Results 1 to 10 of about 683 (129)

Antiviral Activity of (1S,9aR)-1-[(1,2,3-Triazol-1-yl)methyl]octahydro-1H-quinolizines from the Alkaloid Lupinine [PDF]

Molecules
Influenza is a disease of significant morbidity and mortality. The number of anti-influenza drugs is small; many of them stimulate the appearance of resistant strains.
Zhangeldy S. Nurmaganbetov, Oralgazy A. Nurkenov, Andrei I. Khlebnikov, Serik D. Fazylov, Roza B. Seidakhmetova, Zhanar K. Tukhmetova, Altynaray T. Takibayeva, Gaukhar Khabdolda, Zhanar B. Rakhimberlinova, Aigul K. Kaldybayeva, Elvira E. Shults   +10 more
doaj   +2 more sources

Imidazo[1,5-a]pyridines - A Versatile Platform for Structurally Distinct N-Heterocyclic Olefins and π-Extended Heterocycles. [PDF]

Angew Chem Int Ed Engl
The synthesis of N‐heterocyclic olefins (NHOs) based on an imidazo[1,5‐a]pyridine scaffold is described. While C5‐alkyl or aryl substituents yield stable NHOs, alkenyl or alkynyl groups at C5 induce 6‐endo cyclization to form (dihydro)imidazo[2,1,5‐de]quinolizines with strong paratropic ring currents.
Esken R, Antoni PW, Lorenz Y, Burdenski C, Kirchhoff JL, Strohmann C, Hansmann MM.   +6 more
europepmc   +2 more sources

Michael Reactions of Arylidenesulfonylacetonitriles. A New Route to Polyfunctional Benzo[a]quinolizines

Molecules, 2002
Arylidenesulfonylacetonitriles react in acetonitrile with 1-methylisoquinoline and isoquinolin-1-yl-acetonitrile in the presence of piperidine to give benzo[a]quinolizines 6,9 and 7,10, respectively. The structures of the products were established on the
Hamdi M Hassaneen, Hyam A Abdelhadi, Tayseer A Abdallah   +2 more
exaly   +3 more sources

Arylidene Meldrum's Acid: A Versatile Structural Motif for the Design of Enzyme‐Responsive “Covalent‐Assembly” Fluorescent Probes with Tailor‐Made Properties**

Chemistry – An Asian Journal, Volume 18, Issue 12, June 15, 2023., 2023
The missing link!!! A carboxylic acid functionalized Meldrum's acid derivative (3‐(2‐methyl‐4,6‐dioxo‐1,3‐dioxan‐2‐yl)propanoic acid) was identified as a valuable building block to achieve facile late‐stage functionalization of enzyme‐responsive “covalent‐assembly” probes whose activation produces fluorescent coumarin or pyronin dyes.
Kévin Renault, Yoan Capello, Shun Yao, Sami Halila, Anthony Romieu   +4 more
wiley   +1 more source

The modification of volatile and nonvolatile compounds in lupines and faba beans by substrate modulation and lactic acid fermentation to facilitate their use for legume‐based beverages—A review

Comprehensive Reviews in Food Science and Food Safety, Volume 21, Issue 5, Page 4018-4055, September 2022., 2022
Abstract Lupines and faba beans are promising ingredients for the beverage industry. They contain high amounts of protein and can be grown in different climate zones and agricultural areas. Therefore, these legumes appear as ideal raw material for vegan, functional, and sustainable beverages.
Stefan W. Ritter, Martina I. Gastl, Thomas M. Becker   +2 more
wiley   +1 more source

Matrine alleviates cisplatin‐induced acute kidney injury by inhibiting mitochondrial dysfunction and inflammation via SIRT3/OPA1 pathway

Journal of Cellular and Molecular Medicine, Volume 26, Issue 13, Page 3702-3715, July 2022., 2022
Abstract Cisplatin is extensively used to treat malignancies. However, its clinical use is always limited due to the serious side effects, especially the nephrotoxicity. Matrine (MAT), a tetracyclic quinolizine alkaloid found in sophora genus, exerts multiple pharmacological roles, including anti‐oxidative stress, anti‐inflammation and anti‐apoptosis ...
Lu Yuan, Jingchao Yang, Ying Li, Longhui Yuan, Fei Liu, Yujia Yuan, Xiaochi Tang   +6 more
wiley   +1 more source

Regio‐ and Stereoselective Synthesis of Benzoquinolizidines

ChemistrySelect, Volume 7, Issue 9, March 7, 2022., 2022
Organocatalytic enantioselective domino Michael addition‐cyclization‐dehydration reactions and catalytic hydrogenation were carried to prepare benzo[c]quinolizidines with three contiguous chirality centers. The D2PM‐TMS showed the best performance with enantiomeric excess up to 95 %.
Anna Alekszi‐Kaszás, Klára Käfer‐Beke, Tamás R. Varga, Attila Bényei, Tibor Kovács, Attila Mándi, Tibor Kurtán, András Simon, Péter Nemes   +8 more
wiley   +1 more source

Cyclazines‐Structure and Aromaticity or Antiaromaticity on the Magnetic Criterion

European Journal of Organic Chemistry, Volume 2022, Issue 8, February 24, 2022., 2022
The spatial magnetic properties of cyclazines, e. g. of cycl[2.2.3]azine N[2.2.3] and cyclo[3.3.3]azine N[3.3.3], actually, the ring current effect as measurable in 1H NMR spectroscopy, can be calculated, visualized as iso‐chemical‐shielding surfaces (ICSS) of various size and direction [e. g.
Erich Kleinpeter, Andreas Koch
wiley   +1 more source

Preparation of Butadienylpyridines by Iridium‐NHC‐Catalyzed Alkyne Hydroalkenylation and Quinolizine Rearrangement

Chemistry – A European Journal, Volume 27, Issue 46, Page 11868-11878, August 16, 2021., 2021
Magic watchmaker. The Ir‐NHC catalyst efficiently hydroalkenylates alkynes with 2‐vinylpyridine. The interplay of the NHC and acac ligands drives the reaction via IrIII intermediates allowing the selective formation of expected and unexpected butadienylpyridine derivatives.
Ramón Azpíroz, Ingo Greger, Luis A. Oro, Vincenzo Passarelli, Ricardo Castarlenas, Jesús J. Pérez‐Torrente   +5 more
wiley   +1 more source

Cyclative MCRs of Azines and Azinium Salts

European Journal of Organic Chemistry, Volume 2021, Issue 3, Page 326-356, January 22, 2021., 2021
The high atom economic feature of multicomponent reactions may open the way to sustainable pharmaceutical chemical processes. This review covers their recent applications for the synthesis N‐heterocycles emphasizing dearomatizative examples. Since the first discovery by Huigsen and co‐workers fifty years ago, a wide range of organic reactions have ...
Anvar Mirzaei, Gábor Turczel, Márton Nagyházi, Vajk Farkas, Áron Balla, Hai Dang Vu, Robert Tuba   +6 more
wiley   +1 more source