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Drivers, Dynamics and Epidemiology of Antimicrobial Resistance in Animal Production [PDF]

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Lubroth, J   +7 more
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Investigating the impact of hospital antibiotic usage on aquatic environment and aquaculture systems: A molecular study of quinolone resistance in Escherichia coli.

Science of the Total Environment, 2020
Quinolones are one of the most important classes of antibacterials available for the treatment of infectious diseases in humans. However, there is a growing concern about bacterial resistance to antimicrobials including quinolones.
Sneha Kalasseril Girijan   +3 more
semanticscholar   +1 more source

Molecular mechanisms associated with quinolone resistance in Enterobacteriaceae: review and update.

Transactions of the Royal Society of Tropical Medicine and Hygiene, 2020
BACKGROUND Quinolones are broad-spectrum antibiotics, which are used for the treatment of different infectious diseases associated with Enterobacteriaceae.
R. Azargun   +7 more
semanticscholar   +1 more source

(Fluoro)quinolones and quinolone resistance genes in the aquatic environment: A river catchment perspective.

Water Research, 2020
This study provides an insight into the prevalence of (fluoro)quinolones (FQs) and their specific quinolone qnrS resistance gene in the Avon river catchment area receiving treated wastewater from 5 wastewater treatment plants (WWTPs), serving 1.5 million
E. Castrignanò   +12 more
semanticscholar   +1 more source

Plasmid-mediated quinolone resistance

Expert Review of Anti-infective Therapy, 2008
The first plasmid-mediated gene involved in quinolone resistance (qnrA1) was reported in 1998. It codes for a pentapeptide-repeat protein that protects type II topoisomerases from quinolones. Additional related plasmid-mediated genes (qnrB, qnrS and qnrC) and chromosomal homologs of them have also been discovered.
Luis, Martínez-Martínez   +4 more
openaire   +2 more sources

Quinolone Resistance

2003
Quinolone antibacterial agents were first introduced into the clinical environment in the early 1960s. The first qumolone to be clinically used was nalidixic acid, which was used for the treatment of enteric and urinary tract infections. As a result of increased clinical resistance to this drug, its use has declined.
J C, Brown, S G, Amyes
openaire   +2 more sources

Mechanisms of quinolone resistance

Infection, 1994
Two mechanisms of resistance to fluoroquinolones are known: (i) alteration of the molecular target of quinolone action-DNA gyrase, and (ii) reduction of the quinolone accumulation. Mutations altering the N-terminus of the gyrase A subunit, especially those around residues Ser83 and Asp87, significantly reduce the susceptibilities towards all quinolones,
B, Wiedemann, P, Heisig
openaire   +2 more sources

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