Results 231 to 240 of about 60,375 (278)
Some of the next articles are maybe not open access.
Drugs, 1993
This review emphasises the advances in the development of newer quinolones: their broader antimicrobial activity particularly their increased activity against Pneumococcus and anaerobes; their longer half-life and tissue penetration including activity in cerebrospinal fluid; and their excellent efficacy in respiratory, intra-abdominal, pelvic, and skin
openaire +3 more sources
This review emphasises the advances in the development of newer quinolones: their broader antimicrobial activity particularly their increased activity against Pneumococcus and anaerobes; their longer half-life and tissue penetration including activity in cerebrospinal fluid; and their excellent efficacy in respiratory, intra-abdominal, pelvic, and skin
openaire +3 more sources
Obstetrics and Gynecology Clinics of North America, 1992
The fluorinated quinolones are synthetic derivatives of nalidixic acid. They are well absorbed when administered orally and have an extended duration of action. They are of primary value in treating gonorrhea and complicated urinary tract infections in nonpregnant women.
Karen Saravanos, Patrick Duff
openaire +3 more sources
The fluorinated quinolones are synthetic derivatives of nalidixic acid. They are well absorbed when administered orally and have an extended duration of action. They are of primary value in treating gonorrhea and complicated urinary tract infections in nonpregnant women.
Karen Saravanos, Patrick Duff
openaire +3 more sources
Pharmaceutisch Weekblad Scientific Edition, 1986
The first quinolone compound, nalidixic acid, showed activity against a limited number of Gram-negative micro-organisms. 'One step' resistance developed in vitro and during treatment. Resistance was not mediated by transfer of R-plasmids, which is a characteristic of all quinolones.
openaire +3 more sources
The first quinolone compound, nalidixic acid, showed activity against a limited number of Gram-negative micro-organisms. 'One step' resistance developed in vitro and during treatment. Resistance was not mediated by transfer of R-plasmids, which is a characteristic of all quinolones.
openaire +3 more sources
Current Pharmaceutical Design, 1970
Abstract: Following the discovery of nalidixic acid in 1962, numerous structural modifications have been made to the quinolone nucleus to increase antimicrobial activit> and improve pharmacokinetic performance. A major advance occured during the 1980\ with the discovery that a fluorine at position-6 conferred broad and potent antimicrobial activity,
Rajesh Kumar +2 more
openaire +3 more sources
Abstract: Following the discovery of nalidixic acid in 1962, numerous structural modifications have been made to the quinolone nucleus to increase antimicrobial activit> and improve pharmacokinetic performance. A major advance occured during the 1980\ with the discovery that a fluorine at position-6 conferred broad and potent antimicrobial activity,
Rajesh Kumar +2 more
openaire +3 more sources
Journal of Antimicrobial Chemotherapy, 1990
Fluoroquinolones have been in use for the past five years. The agents inhibit Enterobacteriaceae, Pseudomonas aeruginosa, and staphylococci, but some agents lack activity against streptococci and none of the commercially available agents inhibits anaerobic species.
openaire +3 more sources
Fluoroquinolones have been in use for the past five years. The agents inhibit Enterobacteriaceae, Pseudomonas aeruginosa, and staphylococci, but some agents lack activity against streptococci and none of the commercially available agents inhibits anaerobic species.
openaire +3 more sources
Current Opinion in Allergy and Clinical Immunology, 2003
Quinolones are potent antibacterial agents that can cause drug hypersensitivity reactions affecting different organs. A better understanding of the underlying mechanism and the level of crossreactivity within different quinolones is needed to handle and prevent these diseases.The adverse side-effects caused by quinolones are the result of different ...
Paolo, Campi, Werner J, Pichler
openaire +2 more sources
Quinolones are potent antibacterial agents that can cause drug hypersensitivity reactions affecting different organs. A better understanding of the underlying mechanism and the level of crossreactivity within different quinolones is needed to handle and prevent these diseases.The adverse side-effects caused by quinolones are the result of different ...
Paolo, Campi, Werner J, Pichler
openaire +2 more sources
Pharmaceutisch Weekblad Scientific Edition, 1986
The quinolones are synthetic antibiotics chemically related to nalidixic acid. Since its introduction, several structural analogues have been synthesized. A fundamental breakthrough was the addition of a fluorine atom. The quinolones interfere with bacterial DNA transcription by inhibiting the enzyme DNA gyrase, that so far has only been found in ...
openaire +2 more sources
The quinolones are synthetic antibiotics chemically related to nalidixic acid. Since its introduction, several structural analogues have been synthesized. A fundamental breakthrough was the addition of a fluorine atom. The quinolones interfere with bacterial DNA transcription by inhibiting the enzyme DNA gyrase, that so far has only been found in ...
openaire +2 more sources
Pharmaceutisch Weekblad Scientific Edition, 1987
Resistance to quinolones is only due to mutations. The mechanism and the range of quinolones involved, depend on the locus of the chromosomal mutation e.g. a mutation in the gyr A locus is associated with resistance due to changes in the gyrase. Using high inocula in vitro, varying, but relatively low mutation rates of resistance to fluoroquinolones ...
openaire +3 more sources
Resistance to quinolones is only due to mutations. The mechanism and the range of quinolones involved, depend on the locus of the chromosomal mutation e.g. a mutation in the gyr A locus is associated with resistance due to changes in the gyrase. Using high inocula in vitro, varying, but relatively low mutation rates of resistance to fluoroquinolones ...
openaire +3 more sources
Seminars in Respiratory Infections, 2001
New fluoroquinolones and fluoronaphthyridones continue to provide the mainstay of antibiotic development, despite recent events associated with unexpected or uncharacteristically severe adverse drug reactions. These have included hepatotoxicity caused by trovafloxacin (suspended), cardiotoxicity associated with grepafloxacin, and phototoxicity caused ...
openaire +3 more sources
New fluoroquinolones and fluoronaphthyridones continue to provide the mainstay of antibiotic development, despite recent events associated with unexpected or uncharacteristically severe adverse drug reactions. These have included hepatotoxicity caused by trovafloxacin (suspended), cardiotoxicity associated with grepafloxacin, and phototoxicity caused ...
openaire +3 more sources
Drugs, 1999
Pharmacokinetic studies of fluoroquinolone antibacterials generally demonstrate some quantitative alterations in elderly compared with younger populations. The most common observations are an increased maximal plasma drug concentration and area under the concentration-time curve, which are primarily attributable to the 10 to 15% decrease in lean body ...
openaire +2 more sources
Pharmacokinetic studies of fluoroquinolone antibacterials generally demonstrate some quantitative alterations in elderly compared with younger populations. The most common observations are an increased maximal plasma drug concentration and area under the concentration-time curve, which are primarily attributable to the 10 to 15% decrease in lean body ...
openaire +2 more sources