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Quinolones

Medical Clinics of North America, 1995
Fluoroquinolones represent a major advance in antimicrobial chemotherapy. Currently, there are five fluoroquinolones approved by the FDA, and many more quinolones are expected to become available in years to come. Although their clinical utility is constantly expanding, they have been best studied in complicated urinary tract infections, chronic ...
B, Suh, B, Lorber
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Quinolones in dermatology

Clinics in Dermatology, 2003
T he quinolones are an important class of broad-spectrum antimicrobials in common use today. Multiple quinolones are currently available in the United States (Table 1) with broader spectrums and longer half-lives than older quinolones, such as nalidixic acid (Fig 1A).
David Sable, George J. Murakawa
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Toxicity of Quinolones

Drugs, 1999
Reactions of the gastrointestinal tract, the CNS and the skin are the most often observed adverse effects during therapy with fluoroquinolones. At least for some of the newer fluoroquinolones a steep dose-response relationship of adverse effects seems to exist. Pathogenesis of the neurotoxic effects of fluoroquinolones is still unknown. Among the newer
Ralf Stahlmann, Hartmut Lode
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Quinolones in the Elderly [PDF]

open access: possibleDrugs, 1995
Aging results in a number of physiological changes that can affect drug disposition; these include reduced gastric acidity, decreased intestinal motility, lower lean body mass, and reduction in renal function. The age-related decline in renal function is the most important of these factors when administering quinolones to elderly patients.
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Switchable Access to 3-Carboxylate-4-quinolones and 1-Vinyl-3-carboxylate-4-quinolones via Oxidative Cyclization of Isatins and Alkynes.

Organic Letters, 2018
An efficient transition-metal-free oxidative cyclization reaction using isatins and alkynes for the facile synthesis of structurally diverse 4-quinolones has been developed.
Shi-Fen Jiang   +6 more
semanticscholar   +1 more source

[Quinolones].

Enfermedades infecciosas y microbiologia clinica, 2003
Quinolones act by inhibiting enzymes (topoisomerases), which are indispensable to DNA synthesis. Their bactericidal activity is concentration-dependent. Their spectrum has become broader, especially since the introduction of a fluorine atom at position 6 (fluoroquinolones).
Demosthenes G. Katritsis, A. John Camm
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