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2003
Quinolone antibacterial agents were first introduced into the clinical environment in the early 1960s. The first qumolone to be clinically used was nalidixic acid, which was used for the treatment of enteric and urinary tract infections. As a result of increased clinical resistance to this drug, its use has declined.
J C, Brown, S G, Amyes
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Quinolone antibacterial agents were first introduced into the clinical environment in the early 1960s. The first qumolone to be clinically used was nalidixic acid, which was used for the treatment of enteric and urinary tract infections. As a result of increased clinical resistance to this drug, its use has declined.
J C, Brown, S G, Amyes
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Mayo Clinic Proceedings, 1987
The fluoroquinolones are a new class of antimicrobial agents structurally related to nalidixic acid. They have a broad spectrum of activity against pathogens, including Pseudomonas aeruginosa, other multiresistant gram-negative bacteria, and methicillin-resistant Staphylococcus aureus but not anaerobes. They are well absorbed after oral administration,
Walker Rc, Wright Aj
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The fluoroquinolones are a new class of antimicrobial agents structurally related to nalidixic acid. They have a broad spectrum of activity against pathogens, including Pseudomonas aeruginosa, other multiresistant gram-negative bacteria, and methicillin-resistant Staphylococcus aureus but not anaerobes. They are well absorbed after oral administration,
Walker Rc, Wright Aj
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Quinolone pharmacokinetics in the elderly
The American Journal of Medicine, 1992As a class, quinolones undergo both renal excretion and hepatic metabolism. The dominant elimination pathway is usually renal, where secretion by the proximal tubule results in renal clearances 1.5-4 times greater than creatinine clearance. The benefit of this two-pathway elimination is protection from excessive accumulation in patients with single ...
Jerome J. Schentag, Thomas F. Goss
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Fluorinated quinolones — new quinolone antimicrobials
1992Paul Ehrlich started his research, called experimental chemotherapy, in 1902, and discovered Trypanrot in 1904 and Salvarsan in 1909. This was the first success of chemotherapy using man-made chemotherapeutic agents against microorganisms. Since the original observation by Fleming in 1929 of the effect of Penicillium notatum on a culture plate in his ...
K. Hirai +16 more
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Quinolones in Gastrointestinal Infections
Chemotherapy, 1996Fluoroquinolones are efficient antimicrobial drugs for the treatment of enteric fever, shigellosis, Escherichia coli diarrhea, cholera, and traveler's diarrhea. They also play a role in the therapy of yersiniosis, campylobacteriosis, and intestinal salmonellosis. A single dose of quinolones has been effective in the treatment of traveler's diarrhea and
H. Laferl +3 more
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International Journal of Antimicrobial Agents, 1992
Fluoroquinolones have broad antibacterial spectra and are active against most Gram-negative and many Gram-positive species. They exhibit excellent oral bioavailability, extensive tissue penetration, low protein binding, and a long elimination half-life.
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Fluoroquinolones have broad antibacterial spectra and are active against most Gram-negative and many Gram-positive species. They exhibit excellent oral bioavailability, extensive tissue penetration, low protein binding, and a long elimination half-life.
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Clinical Pharmacokinetics, 1992
The fluoroquinolones represent a relatively new class of antibiotics with outstanding therapeutic potential, attributable to their broad spectrum of antimicrobial activity and favourable tissue distribution. They are highly active against most Gram-negative pathogens, as well as Staphylococcus aureus and coagulase-negative staphylococci.
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The fluoroquinolones represent a relatively new class of antibiotics with outstanding therapeutic potential, attributable to their broad spectrum of antimicrobial activity and favourable tissue distribution. They are highly active against most Gram-negative pathogens, as well as Staphylococcus aureus and coagulase-negative staphylococci.
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Use of the Quinolones in Paediatrics
Drugs, 1993For many years, quinolone-induced cartilage toxicity observed in experiments involving immature animals has represented an indisputable contraindication for the use of these promising antimicrobials in prepubertal patients. Clinical, magnetic resonance imaging and histopathological monitoring of patients receiving ciprofloxacin at the University of ...
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Drug interactions with quinolones
Journal of Antimicrobial Chemotherapy, 1990The pharmacodynamic and pharmacokinetic drug interactions and pharmaceutical compatibilities of fluoroquinolones are reviewed. Incompatibilities are observed between quinolones and penicillins such as flucloxacillin and amoxicillin and with clindamycin when mixed in an administration set.
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Photosensitivity and the quinolones
Journal of the European Academy of Dermatology and Venereology, 1995Lawrence Charles Parish +1 more
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