Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley +1 more source
Durable goods, price indexes and quality change: an application to automobile prices in Italy, 1988-1998. [PDF]
The paper analyzes the problems of measurement of durable consumer prices posed by quality change. Theoretical price indexes are defined and used to analyze several empirical methods of estimation of quality adjusted price indexes.
Gian Maria Tomat
core
The consistency of empirical comparisons of regression and analogy-based software project cost prediction [PDF]
, 2005 OBJECTIVE - to determine the consistency within and between results in empirical studies of software engineering cost estimation. We focus on regression and analogy techniques as these are commonly used.
Mair, CM, Shepperd, M J
core
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
The Exchange Rate Pass-through into Import Prices: The Case of Japanese Meat Imports [PDF]
The effect of exchange rate pass-through on import prices is a question of significant interest to many nations and especially those with permanent trade deficit.
Miljkovic, Dragan, Zhuang, Renan
core +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Regulatory structure and risk and infrastructure firms : an international comparison [PDF]
Evidence about how choice of regulatory regimes affects the level of shareholder risk for the regulated company has traditionally focused on studies in the United Kingdom and the United States.
Alexander, Ian +2 more
core
A Methodology for Variability Reduction in Manufacturing Cost Estimating in the Automotive Industry based on Design Features [PDF]
, 2009 Organised by: Cranfield UniversitySmall to medium manufacturing companies are coming to realise the increasing importance of performing fast and accurate cost estimates at the early stages of projects to address customers’ requests for quotation ...
Romero Rojo, Francisco Javier +2 more
core