Results 41 to 50 of about 531,576 (329)

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

A randomized, placebo‐controlled first‐in‐human study of oral TQS‐168 in healthy volunteers: Assessment of safety, tolerability, pharmacokinetics, pharmacodynamics, and food effect

Clinical and Translational Science
TQS‐168, a first‐in‐class small‐molecule inducer of peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha gene expression, is in development for the treatment of amyotrophic lateral sclerosis.
Jonas Hannestad, Steven Smith, Andrew Lam, Janet Hurt, Nicole Harada, Richard Kim, Abhirup Das, Juliana Brunello, Gareth Whitaker, David Chalmers, Faria Senjoti, Wu Lin, James Coghill, Yogesh Bansal, Sharan Sidhu, Vanessa Zann, Enchi Liu   +16 more
doaj   +1 more source

Effects of virtual reality motor games on motor skills in children with cerebral palsy: a systematic review and meta-analysis

Frontiers in Psychology
BackgroundEnhancing motor skills is crucial for the functional development of children with cerebral palsy. Virtual reality has emerged as a promising technology for rehabilitating these children.ObjectiveThe objective of this study was to systematically
Zhuolin Xue, Zhuolin Xue, Weiqiang Zhang, Ni Zhou, Pengwei Ma, Pengwei Ma, Kun Yuan, Kun Yuan, Peiyun Zheng, Peiyun Zheng, Junfeng Li, Jindong Chang, Jindong Chang   +12 more
doaj   +1 more source

Isomorphism Theorems on Quasi Module

Discussiones Mathematicae - General Algebra and Applications, 2019
A quasimodel is an algebraic axiomatisation of the hyperspace structure based on a module. We initiated this structure in our paper [2]. It is a generalisation of the module structure in the sense that every module can be embedded into a quasi module and
Jana Sandip, Mazumder Supriyo
doaj   +1 more source

Presenting Quotient Locales

Applied Categorical Structures, 2023
AbstractIt is often useful to be able to deal with locales in terms of presentations of their underlying frames, or equivalently, the geometric theories which they classify. Given a presentation for a locale, presentations for its sublocales can be obtained by simply appending additional relations, but the case of quotient locales is more subtle.
openaire   +3 more sources

On Stable Quotients

Notre Dame Journal of Formal Logic, 2022
We solve two problems from the paper "On maximal stable quotients of definable groups in NIP theories" by M. Haskel and A. Pillay, which concern maximal stable quotients of groups type-definable in NIP theories. The first result says that if $G$ is a type-definable group in a distal theory, then $G^{st}=G^{00}$ (where $G^{st}$ is the smallest type ...
Krupiński, Krzysztof, Portillo, Adrián
openaire   +3 more sources

The MMP‐9/TIMP‐1 Ratio and Concentrations of Osteopontin Are Elevated in Cerebrospinal Fluid of People With Multiple Sclerosis and Decrease After Autologous Hematopoietic Stem Cell Transplantation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the utility of cerebrospinal fluid (CSF) biomarkers—matrix metalloproteinase‐9 (MMP‐9), tissue inhibitor of metalloproteinases‐1 (TIMP‐1), the MMP‐9/TIMP‐1 ratio, and osteopontin (OPN)—as indicators of blood–brain barrier (BBB) integrity and disease activity in people with relapsing–remitting multiple sclerosis (pwMS ...
Ivan Pavlovic, Ida Erngren, Kim Kultima, Anders Larsson, Malin Müller, Anna Wiberg, Joachim Burman   +6 more
wiley   +1 more source

The hypercomplex quotient and the quaternionic quotient

Mathematische Annalen, 1991
Quotient constructions are defined for hypercomplex and quaternionic manifolds that are analogous to those given for hyperkähler manifolds by \textit{N. J. Hitchin}, \textit{A. Karlhede}, \textit{U. Lindström} and \textit{M. Roček} [Commun. Math. Phys. 108, 535-589 (1987; Zbl 0612.53043)] and for quaternionic Kähler manifolds by \textit{K. Galicki} and
openaire   +1 more source

Real‐World Performance of CSF Kappa Free Light Chains in the 2024 McDonald Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Kappa free light chains (KFLCs) in the cerebrospinal fluid (CSF) have a similar performance to CSF‐restricted oligoclonal bands (OCB) for multiple sclerosis (MS) diagnosis. To help with implementation, we set out to resolve several remaining uncertainties: (1) performance in a real‐world cohort and the 2024 McDonald criteria; (2 ...
Maya M. Leibowitz, Ryan Cooper, Stefania Kaninia, Kathryn I. Challis, Will Greenway, Maria Bonello, Mahmoud Elbahnasawi, Deborah T. Shode, Dominika Gajdasik, Victor Iliev, Alison M. E. Whitelegg, Ian Galea   +11 more
wiley   +1 more source

Effects of Biological Sex and Age on Cerebrospinal Fluid Markers—A Retrospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebrospinal fluid (CSF) analysis is a key diagnostic tool for neurological diseases. To date, only a few studies have investigated in larger cohorts the effect of age and biological sex on diagnostic markers extracted from CSF. Methods For this retrospective observational study, 4163 CSF findings (2012–2020) were evaluated.
Isabel‐Sophie Hafer, Simon Faissner, Ralf Gold, Aiden Haghikia   +3 more
wiley   +1 more source