Results 91 to 100 of about 5,353,584 (244)
Organizational Design of R&D Activities [PDF]
, 2000 This paper addresses the question of whether R&D should be carried out by an independent research unit or be produced in-house by the firm marketing the innovation. We define two organizational structures. In an integrated structure, the firm that markets the innovation also carries out and finances research leading to the innovation. In an independent
AMBEC, Stefan, POITEVIN, Michel
openaire +2 more sources
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Characterising Silicone Rubber: Indentation and Dynamic Modelling
R&D JournalRubber’s unique elastic and viscous properties make it essential in engineering applications, particularly in industries such as automotive, construction, and mining.
Kamogelo D. Malatsi, Gerhard Venter
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Drug Design, Development and TherapyEduardo Anitua,1,2 Roberto Tierno,1,2 Gorka Orive,1,2 Mohammad Hamdan Alkhraisat1,2 1Department of Regenerative Medicine, BTI Biotechnology Institute, Vitoria, Alava, Spain; 2Department of Regenerative Medicine, University Institute for Regenerative ...
Anitua E +3 more
doaj
Quasi-statically actuated MEMS scanner with concentric vertical comb electrodes
Micro and Nano Systems LettersA quasi-static (QS) MEMS mirror scanner with concentric vertical combs (CVC) is presented. The increase rate of overlapped area of the CVC, tends to show larger values and more uniform than that of conventional vertical combs, resulting in improved ...
Daehwan Chae +4 more
doaj +1 more source