Results 111 to 120 of about 547,362 (254)

El concierto económico y el cálculo del cupo: una comparación de sus resultados con los del sistema de financiación común [PDF]

open access: yes, 2013
El objetivo de este trabajo es analizar el funcionamiento del sistema de concierto económico (convenio) que regula la financiación de las Comunidades Forales, haciendo un especial hincapié en la metodología de cálculo del cupo y los resultados ...
García Díaz, Miguel Ángel   +4 more
core  

Safety and Effectiveness of Sutimlimab in Cold Agglutinin Disease: A Real‐World International Experience

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT Sutimlimab is a monoclonal antibody against complement fraction C1s approved for the treatment of hemolytic anemia due to cold agglutinin disease (CAD). Here, we analyzed and report the largest international CAD cohort of sutimlimab‐treated patients ever reported to highlight its safety and effectiveness in the real‐world setting. We accrued a
Bruno Fattizzo   +38 more
wiley   +1 more source

El sector ganadero bovino colombiano y sus problemáticas fiscales. Análisis del alcance del régimen simple de tributación

open access: yesRevista de Derecho Fiscal
El sector ganadero colombiano, por muchos años, ha sido marginado en las políticas públicas que se adoptan en Colombia, en especial aquellas que regulan los tributos.
Julián Eduardo Saray Castillo
doaj   +1 more source

The Role of Bispecific Antibodies in Relapsed/Refractory Multiple Myeloma With Renal Impairment: A Systematic Review

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT Renal impairment (RI), defined as estimated glomerular filtration rate less than 60 mL/min with or without the need for dialysis, is a frequent and severe complication in patients with relapsed/refractory multiple myeloma (RRMM), as it can affect patient prognosis, drug metabolism and treatment options.
Ioannis Ntanasis‐Stathopoulos   +7 more
wiley   +1 more source

COMENTARIOS A LA DIRECTIVA DEL RÉGIMEN FISCAL DE REORGANIZACIONES EMPRESARIALES

open access: yesCrónica Tributaria, 2005
ÁMBITO SUBJETIVO: Sociedades cubiertas por la Directiva. Los socios. FUSIONES, ESCISIONES Y APORTACIONES DE ACTIVOS: Conceptos. Fusiones(Escisiones. Aportaciones de activos). Régimen fiscal de la sociedad transmitente.
Juan López Rodríguez
doaj  

¿Quo Vadis? Reclutamiento y Contratacion de Trabajadores Migrantes y su Acceso a la Seguridad Social: dinamicas de los sistemas de trabajo temporal migratorio en Norte y Centroamerica [PDF]

open access: yes, 2013
Different regions and countries of the world face a serious need to design and make use of necessary policies and resources to better manage worker migration, thus ensuring the welfare and human rights of these people who, in the end, are of benefit to ...
Alejandra Costanza, Gisele Lisa Bonnici
core  

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma   +2 more
wiley   +1 more source

Responsabilidad Tributaria y Administración Concursal [PDF]

open access: yes, 2014
Una circunstancia extratributaria que puede ser relevante a la hora de configurar los diferentes supuestos de la responsabilidad tributaria es el desarrollo de un procedimiento concursal frente al obligado tributario.
Martínez Giner, Luis Alfonso
core  

Clotrimazole‐loaded PLGA microparticles for local drug delivery to the vagina: Shape does matter

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Clotrimazole‐loaded PLGA microparticles for intravaginal delivery. Abstract Background Intravaginal drug administration is the most promising strategy for treating vaginal infections to protect women's health, such as vulvovaginal candidiasis (VVC). However, conventional vaginal formulations in the clinic face challenges such as drug leakage and low ...
Yanyu Li   +8 more
wiley   +1 more source

Tensile Stimulation in Biorelevant Culture Conditions Enhances MSC and TPSC Tenogenesis on Aligned Electrospun Scaffolds

open access: yesAdvanced NanoBiomed Research, EarlyView.
Biomimetic electrospun scaffold incorporating GDF‐7‐loaded mesoporous silica nanoparticles, combined with mechanical stimulation and physiological oxygen tension, guides tenogenic differentiation of mesenchymal stromal cell and tendon progenitor stem cell. This integrated approach enhances cell proliferation, matrix deposition, and tendon‐specific gene
Vera Citro   +3 more
wiley   +1 more source

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